======= PKD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKD2
  * **<color #00a2e8>Official Name</color>**: polycystin 2, transient receptor potential cation channel
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5311|5311]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13563|Q13563]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:16551655, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:20881056, ECO:0000269|PubMed:27991905, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|PKD channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal cortex development|
|metanephric cortical collecting duct development|
|cellular response to hydrostatic pressure|
|metanephric cortex development|
|cortical collecting duct development|
|metanephric smooth muscle tissue development|
|renal artery morphogenesis|
|kidney smooth muscle tissue development|
|polycystin complex|
|detection of nodal flow|
|HLH domain binding|
|calcium-induced calcium release activity|
|ascending thin limb development|
|metanephric ascending thin limb development|
|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|
|metanephric part of ureteric bud development|
|detection of endogenous stimulus|
|voltage-gated cation channel activity|
|cellular response to water stimulus|
|basal cortex|
|metanephric S-shaped body morphogenesis|
|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|
|metanephric loop of Henle development|
|response to hydrostatic pressure|
|determination of liver left/right asymmetry|
|integral component of cytoplasmic side of endoplasmic reticulum membrane|
|metanephric distal tubule development|
|renal system vasculature morphogenesis|
|S-shaped body morphogenesis|
|kidney vasculature morphogenesis|
|mesonephric duct development|
|cation channel complex|
|loop of Henle development|
|actinin binding|
|distal tubule development|
|outward rectifier potassium channel activity|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|metanephric mesenchyme development|
|negative regulation of release of sequestered calcium ion into cytosol|
|response to water|
|metanephric nephron tubule development|
|positive regulation of sequestering of calcium ion|
|nephric duct development|
|metanephric nephron epithelium development|
|smooth muscle tissue development|
|cytoplasmic sequestering of transcription factor|
|cation channel activity|
|negative regulation of calcium ion transport into cytosol|
|cellular response to fluid shear stress|
|metanephric tubule development|
|kidney mesenchyme development|
|voltage-gated sodium channel activity|
|metanephric nephron morphogenesis|
|renal system vasculature development|
|kidney vasculature development|
|metanephric epithelium development|
|muscle alpha-actinin binding|
|cytoplasmic sequestering of protein|
|regulation of ryanodine-sensitive calcium-release channel activity|
|metanephros morphogenesis|
|potassium channel activity|
|integral component of lumenal side of endoplasmic reticulum membrane|
|placenta blood vessel development|
|negative regulation of calcium-mediated signaling|
|centrosome duplication|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|metanephric nephron development|
|protein heterotetramerization|
|non-motile cilium|
|filamentous actin|
|response to fluid shear stress|
|basal plasma membrane|
|positive regulation of cyclin-dependent protein kinase activity|
|phosphoprotein binding|
|cellular response to osmotic stress|
|negative regulation of calcium ion transmembrane transporter activity|
|receptor signaling pathway via JAK-STAT|
|positive regulation of calcium ion transmembrane transporter activity|
|negative regulation of calcium ion transmembrane transport|
|positive regulation of nitric oxide biosynthetic process|
|regulation of calcium ion import|
|receptor signaling pathway via STAT|
|voltage-gated calcium channel activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|positive regulation of nitric oxide metabolic process|
|negative regulation of cation channel activity|
|positive regulation of calcium-mediated signaling|
|voltage-gated ion channel activity|
|branching involved in ureteric bud morphogenesis|
|detection of mechanical stimulus|
|positive regulation of reactive oxygen species biosynthetic process|
|aorta development|
|ureteric bud morphogenesis|
|calcium channel activity|
|positive regulation of calcium ion transport into cytosol|
|cellular response to cAMP|
|mesonephric tubule morphogenesis|
|ciliary membrane|
|release of sequestered calcium ion into cytosol|
|regulation of nitric oxide biosynthetic process|
|negative regulation of sequestering of calcium ion|
|negative regulation of calcium ion transport|
|heart looping|
|voltage-gated potassium channel activity|
|artery morphogenesis|
|nephron tubule morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|calcium ion transmembrane import into cytosol|
|renal tubule morphogenesis|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|calcium ion transport into cytosol|
|embryonic heart tube development|
|cytoskeletal protein binding|
|nephron tubule development|
|response to osmotic stress|
|mitotic spindle|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|positive regulation of cell cycle arrest|
|ATPase binding|
|renal tubule development|
|centrosome cycle|
|negative regulation of cation transmembrane transport|
|cellular response to calcium ion|
|metanephros development|
|kidney morphogenesis|
|regulation of reactive oxygen species biosynthetic process|
|artery development|
|ureteric bud development|
|mesonephric tubule development|
|embryonic placenta development|
|mesonephric epithelium development|
|regulation of calcium ion transmembrane transporter activity|
|cytosolic calcium ion transport|
|sodium ion transmembrane transport|
|mesonephros development|
|microtubule organizing center organization|
|protein homotetramerization|
|positive regulation of reactive oxygen species metabolic process|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|nephron epithelium development|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|response to cAMP|
|regulation of calcium ion transport into cytosol|
|motile cilium|
|negative regulation of G1/S transition of mitotic cell cycle|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of ion transmembrane transporter activity|
|negative regulation of cell cycle G1/S phase transition|
|maintenance of protein location|
|protein heterooligomerization|
|spinal cord development|
|regulation of cell cycle arrest|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|determination of left/right symmetry|
|detection of external stimulus|
|positive regulation of calcium ion transport|
|detection of abiotic stimulus|
|determination of bilateral symmetry|
|specification of symmetry|
|nephron development|
|regulation of sequestering of calcium ion|
|ion channel binding|
|liver development|
|hepaticobiliary system development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|cellular response to reactive oxygen species|
|ciliary basal body|
|response to organophosphorus|
|positive regulation of cation transmembrane transport|
|cytoplasmic vesicle membrane|
|cell cycle arrest|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|protein tetramerization|
|regulation of G1/S transition of mitotic cell cycle|
|response to calcium ion|
|response to purine-containing compound|
|placenta development|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|morphogenesis of a branching epithelium|
|neural tube development|
|negative regulation of DNA-binding transcription factor activity|
|maintenance of location|
|regulation of cell cycle G1/S phase transition|
|potassium ion transport|
|morphogenesis of a branching structure|
|cell-cell junction|
|regulation of cation channel activity|
|lamellipodium|
|regulation of reactive oxygen species metabolic process|
|cellular response to metal ion|
|response to reactive oxygen species|
|calcium ion transmembrane transport|
|cilium|
|positive regulation of transmembrane transport|
|cellular response to acid chemical|
|negative regulation of mitotic cell cycle phase transition|
|response to mechanical stimulus|
|cellular response to inorganic substance|
|mesenchyme development|
|negative regulation of cell cycle phase transition|
|cellular response to oxidative stress|
|regulation of calcium ion transport|
|calcium ion transport|
|heart morphogenesis|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|kidney development|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|renal system development|
|positive regulation of cell cycle process|
|embryonic organ morphogenesis|
|divalent metal ion transport|
|muscle tissue development|
|divalent inorganic cation transport|
|negative regulation of mitotic cell cycle|
|epithelial tube morphogenesis|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|urogenital system development|
|negative regulation of cell cycle process|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|protein homooligomerization|
|response to acid chemical|
|regulation of neurotransmitter levels|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|cilium organization|
|response to metal ion|
|in utero embryonic development|
|positive regulation of cell cycle|
|regulation of metal ion transport|
|response to oxidative stress|
|monovalent inorganic cation transport|
|blood vessel morphogenesis|
|gland development|
|regulation of mitotic cell cycle phase transition|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|cellular calcium ion homeostasis|
|regulation of cell cycle phase transition|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|microtubule cytoskeleton organization|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|blood vessel development|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|protein complex oligomerization|
|heart development|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|microtubule-based process|
|negative regulation of cell population proliferation|
|detection of stimulus|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|ion homeostasis|
|regulation of protein kinase activity|
|cation transport|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|animal organ morphogenesis|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|cell cycle process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|cytoskeleton organization|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|transmembrane transport|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.17|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.86|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.73|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.72|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.97|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6351
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKD2 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>