======= PLA2G2D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G2D
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IID
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26279|26279]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNK4|Q9UNK4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G2D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G2D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholip A2 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|
|regulatory T cell differentiation|
|heparan sulfate proteoglycan binding|
|calcium-dependent phospholipase A2 activity|
|phosphatidylinositol acyl-chain remodeling|
|phosphatidylglycerol acyl-chain remodeling|
|phosphatidylserine acyl-chain remodeling|
|arachidonic acid secretion|
|arachidonate transport|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|icosanoid secretion|
|phospholipase A2 activity|
|phosphatidylglycerol metabolic process|
|icosanoid transport|
|phosphatidylserine metabolic process|
|fatty acid derivative transport|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|alpha-beta T cell differentiation|
|long-chain fatty acid transport|
|negative regulation of T cell proliferation|
|alpha-beta T cell activation|
|fatty acid transport|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|phosphatidylcholine metabolic process|
|negative regulation of leukocyte proliferation|
|acid secretion|
|phospholipid binding|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|T cell differentiation|
|monocarboxylic acid transport|
|negative regulation of lymphocyte activation|
|regulation of T cell proliferation|
|phosphatidylinositol metabolic process|
|heparin binding|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|ammonium ion metabolic process|
|negative regulation of cell activation|
|cellular modified amino acid metabolic process|
|glycerophospholipid biosynthetic process|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|glycerolipid biosynthetic process|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|phospholipid biosynthetic process|
|negative regulation of cell adhesion|
|carboxylic acid transport|
|organic acid transport|
|regulation of leukocyte cell-cell adhesion|
|lipid transport|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|regulation of T cell activation|
|lipid localization|
|leukocyte differentiation|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|organic anion transport|
|inflammatory response|
|regulation of lymphocyte activation|
|organophosphate biosynthetic process|
|hemopoiesis|
|lipid biosynthetic process|
|anion transport|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|calcium ion binding|
|organophosphate metabolic process|
|leukocyte activation|
|cellular lipid metabolic process|
|cell activation|
|secretion|
|lipid metabolic process|
|defense response|
|ion transport|
|regulation of cell population proliferation|
|regulation of immune system process|
|organic substance catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.74|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.8|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.86|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.97|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8720
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G2D Expression in NALM6 Cells: 2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>