======= PLA2G4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G4A
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IVA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5321|5321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47712|P47712]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600522|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|PLA2 B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet activating factor biosynthetic process|
|cardiolipin acyl-chain remodeling|
|platelet activating factor metabolic process|
|cardiolipin metabolic process|
|calcium-dependent phospholipase A2 activity|
|phosphatidylinositol acyl-chain remodeling|
|phosphatidylglycerol acyl-chain remodeling|
|glycerophospholipid catabolic process|
|phosphatidylserine acyl-chain remodeling|
|lysophospholipase activity|
|arachidonate transport|
|arachidonic acid secretion|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|icosanoid secretion|
|phospholipase A2 activity|
|phosphatidylglycerol metabolic process|
|icosanoid transport|
|phosphatidylserine metabolic process|
|fatty acid derivative transport|
|phospholipid catabolic process|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|icosanoid biosynthetic process|
|glycerolipid catabolic process|
|calcium-dependent phospholipid binding|
|arachidonic acid metabolic process|
|long-chain fatty acid transport|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|acid secretion|
|lipid droplet|
|fatty acid derivative biosynthetic process|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|cellular response to antibiotic|
|organophosphate catabolic process|
|monocarboxylic acid transport|
|fatty acid derivative metabolic process|
|phosphatidylinositol metabolic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|cellular modified amino acid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|cytoplasmic vesicle|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|response to antibiotic|
|organic acid biosynthetic process|
|glycerophospholipid metabolic process|
|lipid localization|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|mitochondrial inner membrane|
|organic anion transport|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|calcium ion binding|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|secretion|
|lipid metabolic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|regulation of cell population proliferation|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14706
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G4A Expression in NALM6 Cells: -4.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>