======= PLA2G4C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G4C
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IVC
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8605|8605]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UP65|Q9UP65]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G4C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G4C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603602|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:9705332}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLA2 B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-independent phospholipase A2 activity|
|phospholipase A1 activity|
|calcium-dependent phospholipase A2 activity|
|parturition|
|phosphatidylinositol acyl-chain remodeling|
|lysophospholipase activity|
|glycerophospholipid catabolic process|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|phospholipase A2 activity|
|phospholipid catabolic process|
|glycerolipid catabolic process|
|calcium-dependent phospholipid binding|
|arachidonic acid metabolic process|
|phosphatidylcholine metabolic process|
|phospholipid binding|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|organophosphate catabolic process|
|cell cortex|
|fatty acid derivative metabolic process|
|phosphatidylinositol metabolic process|
|nuclear envelope|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|multi-multicellular organism process|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|inflammatory response|
|monocarboxylic acid metabolic process|
|calcium ion binding|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|defense response|
|reproductive process|
|reproduction|
|intracellular signal transduction|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8046
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G4C Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>