======= PLA2G6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G6
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group VI
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8398|8398]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60733|O60733]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603604|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
|Patatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serine hydrolase activity|
|positive regulation of arachidonic acid secretion|
|calcium-independent phospholipase A2 activity|
|urinary tract smooth muscle contraction|
|urinary bladder smooth muscle contraction|
|cardiolipin biosynthetic process|
|ATP-dependent protein binding|
|regulation of arachidonic acid secretion|
|phosphatidylglycerol biosynthetic process|
|negative regulation of synaptic transmission, glutamatergic|
|regulation of store-operated calcium channel activity|
|positive regulation of sphingolipid biosynthetic process|
|positive regulation of protein kinase C signaling|
|positive regulation of ceramide biosynthetic process|
|cardiolipin metabolic process|
|regulation of protein kinase C signaling|
|regulation of membrane lipid metabolic process|
|regulation of ceramide biosynthetic process|
|regulation of sphingolipid biosynthetic process|
|positive regulation of icosanoid secretion|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phosphatidylethanolamine acyl-chain remodeling|
|regulation of fatty acid transport|
|phosphatidylcholine acyl-chain remodeling|
|phospholipase A2 activity|
|positive regulation of release of cytochrome c from mitochondria|
|phosphatidylglycerol metabolic process|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of organic acid transport|
|antibacterial humoral response|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of anion transport|
|smooth muscle contraction|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of blood vessel diameter|
|regulation of organic acid transport|
|negative regulation of synaptic transmission|
|positive regulation of lipid transport|
|maternal process involved in female pregnancy|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of insulin secretion|
|phosphatidylcholine metabolic process|
|hydrolase activity|
|positive regulation of lipid biosynthetic process|
|positive regulation of lipid localization|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of exocytosis|
|regulation of anion transport|
|positive regulation of peptide hormone secretion|
|regulation of lipid transport|
|antimicrobial humoral response|
|positive regulation of mitochondrion organization|
|memory|
|positive regulation of hormone secretion|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|regulation of lipid localization|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|Fc-gamma receptor signaling pathway|
|regulation of tube size|
|positive regulation of lipid metabolic process|
|regulation of calcium ion transmembrane transport|
|positive regulation of cellular amide metabolic process|
|microtubule organizing center|
|vascular process in circulatory system|
|regulation of cation channel activity|
|positive regulation of apoptotic signaling pathway|
|regulation of insulin secretion|
|female pregnancy|
|regulation of mitochondrion organization|
|regulation of lipid biosynthetic process|
|ammonium ion metabolic process|
|calmodulin binding|
|glycerophospholipid biosynthetic process|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|glycerolipid biosynthetic process|
|regulation of exocytosis|
|Fc receptor signaling pathway|
|phospholipid biosynthetic process|
|regulation of calcium ion transport|
|muscle contraction|
|response to endoplasmic reticulum stress|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|cognition|
|lipid catabolic process|
|muscle system process|
|glycerophospholipid metabolic process|
|regulation of cytosolic calcium ion concentration|
|phagocytosis|
|defense response to bacterium|
|regulation of cation transmembrane transport|
|humoral immune response|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of metal ion transport|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|regulation of cellular amide metabolic process|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of anatomical structure size|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|behavior|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|response to bacterium|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|positive regulation of immune response|
|organophosphate metabolic process|
|cellular homeostasis|
|regulation of cellular localization|
|defense response to other organism|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|immune effector process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.527|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2732
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G6 Expression in NALM6 Cells: 3.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>