======= PLAA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLAA
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 activating protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9373|9373]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y263|Q9Y263]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLAA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLAA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603873|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). {ECO:0000250|UniProtKB:P27612, ECO:0000269|PubMed:18291623, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PUL|
|WD40|
|PFU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipase A2 activator activity|
|negative regulation of protein K63-linked ubiquitination|
|positive regulation of phospholipase A2 activity|
|ubiquitin recycling|
|negative regulation of protein polyubiquitination|
|positive regulation of synaptic vesicle recycling|
|regulation of protein K63-linked ubiquitination|
|regulation of phospholipase A2 activity|
|positive regulation of neuron migration|
|regulation of protein polyubiquitination|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|positive regulation of dendrite extension|
|regulation of synaptic vesicle recycling|
|regulation of dendrite extension|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|regulation of neuron migration|
|positive regulation of phospholipase activity|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|negative regulation of protein ubiquitination|
|ubiquitin binding|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of lipase activity|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|regulation of synaptic vesicle cycle|
|macroautophagy|
|positive regulation of cell growth|
|fatty acid derivative metabolic process|
|positive regulation of developmental growth|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|regulation of protein ubiquitination|
|cellular response to biotic stimulus|
|regulation of protein modification by small protein conjugation or removal|
|positive regulation of growth|
|process utilizing autophagic mechanism|
|autophagy|
|synapse|
|positive regulation of neuron projection development|
|response to lipopolysaccharide|
|fatty acid metabolic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|response to molecule of bacterial origin|
|regulation of developmental growth|
|proteasomal protein catabolic process|
|positive regulation of neuron differentiation|
|phospholipid metabolic process|
|positive regulation of cell projection organization|
|regulation of cell growth|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to lipid|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|monocarboxylic acid metabolic process|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|cell junction|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|regulation of growth|
|protein catabolic process|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|regulation of cell migration|
|response to lipid|
|organophosphate metabolic process|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|carboxylic acid metabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|generation of neurons|
|response to oxygen-containing compound|
|neurogenesis|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-4.48|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.76|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.24|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.15|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.08|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.01|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.78|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.77|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.75|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.72|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.74|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.78|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.81|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.83|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.92|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.97|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.03|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.03|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.03|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.1|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.1|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.12|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.22|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.26|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.31|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.33|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.35|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.39|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.42|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.42|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.48|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.5|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.52|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.73|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.98|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.04|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.17|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|3.19|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.3|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.32|
|[[:results:exp134|MS023 2μM R03 exp134]]|3.33|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|3.38|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.41|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.62|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.63|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|3.75|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.85|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|3.93|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.94|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|4.1|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|4.12|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|4.13|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|4.19|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|4.4|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|4.69|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|4.73|
|[[:results:exp135|MS023 7μM R03 exp135]]|5.6|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|5.79|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|6.12|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|6.13|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|6.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bak1|BAK1]]|0.759|
|[[:human genes:a:apaf1|APAF1]]|0.756|
|[[:human genes:u:ubqln1|UBQLN1]]|0.741|
|[[:human genes:c:casp9|CASP9]]|0.718|
|[[:human genes:f:faf2|FAF2]]|0.693|
|[[:human genes:m:march5|MARCH5]]|0.688|
|[[:human genes:v:vdac2|VDAC2]]|0.674|
|[[:human genes:d:dohh|DOHH]]|0.665|
|[[:human genes:r:rad23b|RAD23B]]|0.661|
|[[:human genes:d:diablo|DIABLO]]|0.634|
|[[:human genes:h:hars|HARS]]|0.629|
|[[:human genes:h:hspd1|HSPD1]]|0.617|
|[[:human genes:c:cycs|CYCS]]|0.609|
|[[:human genes:h:hccs|HCCS]]|0.606|
|[[:human genes:g:gfpt1|GFPT1]]|0.59|
|[[:human genes:e:eny2|ENY2]]|0.586|
|[[:human genes:r:rptor|RPTOR]]|0.581|
|[[:human genes:t:thg1l|THG1L]]|0.58|
|[[:human genes:t:triap1|TRIAP1]]|0.577|
|[[:human genes:u:ube2k|UBE2K]]|0.577|
|[[:human genes:s:serf2|SERF2]]|0.571|
|[[:human genes:u:ube2g2|UBE2G2]]|0.553|
|[[:human genes:r:romo1|ROMO1]]|0.549|
|[[:human genes:k:kdsr|KDSR]]|0.542|
|[[:human genes:u:uap1|UAP1]]|0.539|
|[[:human genes:a:atad1|ATAD1]]|0.537|
|[[:human genes:m:mtor|MTOR]]|0.535|
|[[:human genes:g:gmppb|GMPPB]]|0.53|
|[[:human genes:g:gabpa|GABPA]]|0.529|
|[[:human genes:m:meaf6|MEAF6]]|0.528|
|[[:human genes:m:mfn1|MFN1]]|0.522|
|[[:human genes:r:rtcb|RTCB]]|0.516|
|[[:human genes:b:bap1|BAP1]]|0.514|
|[[:human genes:r:rnmt|RNMT]]|0.511|
|[[:human genes:a:atp5j|ATP5J]]|0.51|
|[[:human genes:p:pmm2|PMM2]]|0.508|
|[[:human genes:a:alg1|ALG1]]|0.503|
|[[:human genes:s:stau1|STAU1]]|0.503|
|[[:human genes:n:nsd1|NSD1]]|0.499|
|[[:human genes:o:opa1|OPA1]]|0.49|
|[[:human genes:w:wdr59|WDR59]]|0.485|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.484|
|[[:human genes:n:nxt1|NXT1]]|0.483|
|[[:human genes:z:zzz3|ZZZ3]]|0.482|
|[[:human genes:w:wdr24|WDR24]]|0.482|
|[[:human genes:t:trim28|TRIM28]]|0.482|
|[[:human genes:t:taz|TAZ]]|0.48|
|[[:human genes:n:nae1|NAE1]]|0.477|
|[[:human genes:m:metap2|METAP2]]|0.476|
|[[:human genes:u:uba3|UBA3]]|0.476|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.474|
|[[:human genes:d:dpagt1|DPAGT1]]|0.469|
|[[:human genes:p:pelo|PELO]]|0.466|
|[[:human genes:s:sec63|SEC63]]|0.465|
|[[:human genes:a:atp5i|ATP5I]]|0.465|
|[[:human genes:p:ppp5c|PPP5C]]|0.463|
|[[:human genes:c:crls1|CRLS1]]|0.455|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.454|
|[[:human genes:c:csnk2b|CSNK2B]]|0.454|
|[[:human genes:t:timm13|TIMM13]]|0.452|
|[[:human genes:s:srp14|SRP14]]|0.45|
|[[:human genes:k:kctd5|KCTD5]]|0.448|
|[[:human genes:p:pam16|PAM16]]|0.446|
|[[:human genes:t:tamm41|TAMM41]]|0.444|
|[[:human genes:a:atp5o|ATP5O]]|0.444|
|[[:human genes:d:dhps|DHPS]]|0.443|
|[[:human genes:c:cct7|CCT7]]|0.442|
|[[:human genes:g:gtf3a|GTF3A]]|0.441|
|[[:human genes:n:nupl2|NUPL2]]|0.438|
|[[:human genes:a:alg2|ALG2]]|0.438|
|[[:human genes:r:rpe|RPE]]|0.438|
|[[:human genes:c:cbfb|CBFB]]|0.438|
|[[:human genes:m:mlst8|MLST8]]|0.437|
|[[:human genes:v:vhl|VHL]]|0.435|
|[[:human genes:r:rpn1|RPN1]]|0.432|
|[[:human genes:e:elf2|ELF2]]|0.432|
|[[:human genes:s:slc25a26|SLC25A26]]|0.431|
|[[:human genes:p:ppa2|PPA2]]|0.43|
|[[:human genes:v:vezt|VEZT]]|0.429|
|[[:human genes:e:exoc4|EXOC4]]|0.427|
|[[:human genes:a:atp5b|ATP5B]]|0.427|
|[[:human genes:p:pdpk1|PDPK1]]|0.426|
|[[:human genes:d:ddhd2|DDHD2]]|0.426|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.426|
|[[:human genes:p:pisd|PISD]]|0.425|
|[[:human genes:a:aup1|AUP1]]|0.424|
|[[:human genes:a:atp5a1|ATP5A1]]|0.424|
|[[:human genes:u:ubxn7|UBXN7]]|0.422|
|[[:human genes:d:dr1|DR1]]|0.42|
|[[:human genes:s:seh1l|SEH1L]]|0.419|
|[[:human genes:b:bptf|BPTF]]|0.419|
|[[:human genes:e:eif3f|EIF3F]]|0.418|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.417|
|[[:human genes:b:brwd1|BRWD1]]|0.417|
|[[:human genes:e:eno1|ENO1]]|0.416|
|[[:human genes:s:sec61g|SEC61G]]|0.415|
|[[:human genes:u:utp23|UTP23]]|0.414|
|[[:human genes:f:fech|FECH]]|0.412|
|[[:human genes:u:ube2j1|UBE2J1]]|0.411|
|[[:human genes:v:vmp1|VMP1]]|0.41|
|[[:human genes:a:atp2a2|ATP2A2]]|0.409|
|[[:human genes:d:dad1|DAD1]]|0.408|
|[[:human genes:t:taf4|TAF4]]|0.407|
|[[:human genes:p:phb|PHB]]|0.406|
|[[:human genes:a:atxn10|ATXN10]]|0.406|
|[[:human genes:e:eif4e|EIF4E]]|0.405|
|[[:human genes:o:oraov1|ORAOV1]]|0.404|
|[[:human genes:t:tmed10|TMED10]]|0.403|
|[[:human genes:t:tmem41b|TMEM41B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15979
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLAA Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>