======= PLCD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCD4
  * **<color #00a2e8>Official Name</color>**: phospholipase C delta 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84812|84812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRC7|Q9BRC7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605939|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand like|
|PI-PLC-X|
|C2|
|PI-PLC-Y|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol trisphosphate biosynthetic process|
|inositol trisphosphate metabolic process|
|acrosome reaction|
|phosphatidylinositol phospholipase C activity|
|inositol phosphate biosynthetic process|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|single fertilization|
|phosphatidylinositol metabolic process|
|fertilization|
|organic hydroxy compound biosynthetic process|
|nuclear membrane|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|calcium ion binding|
|sexual reproduction|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|lipid metabolic process|
|reproductive process|
|reproduction|
|intracellular signal transduction|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCD4 Expression in NALM6 Cells: 3.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>