======= PLCG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCG2
  * **<color #00a2e8>Official Name</color>**: phospholipase C gamma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5336|5336]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16885|P16885]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI-PLC-Y|
|C2|
|PI-PLC-X|
|SH3 1|
|SH2|
|efhand like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|follicular B cell differentiation|
|activation of store-operated calcium channel activity|
|positive regulation of store-operated calcium channel activity|
|regulation of store-operated calcium channel activity|
|phospholipase C activity|
|inositol trisphosphate biosynthetic process|
|mature B cell differentiation involved in immune response|
|inositol trisphosphate metabolic process|
|mature B cell differentiation|
|positive regulation of receptor internalization|
|phosphatidylinositol phospholipase C activity|
|inositol phosphate biosynthetic process|
|phospholipid catabolic process|
|positive regulation of calcium ion transmembrane transporter activity|
|phosphotyrosine residue binding|
|B cell activation involved in immune response|
|positive regulation of receptor-mediated endocytosis|
|regulation of receptor internalization|
|release of sequestered calcium ion into cytosol|
|inositol phosphate metabolic process|
|negative regulation of sequestering of calcium ion|
|polyol biosynthetic process|
|calcium ion transmembrane import into cytosol|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|phosphatidylinositol-mediated signaling|
|calcium ion transport into cytosol|
|inositol lipid-mediated signaling|
|positive regulation of type I interferon production|
|regulation of calcium ion transmembrane transporter activity|
|cytosolic calcium ion transport|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|positive regulation of ion transmembrane transporter activity|
|B cell differentiation|
|phosphatidylinositol biosynthetic process|
|polyol metabolic process|
|lymphocyte activation involved in immune response|
|positive regulation of transporter activity|
|stimulatory C-type lectin receptor signaling pathway|
|alcohol biosynthetic process|
|innate immune response activating cell surface receptor signaling pathway|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|regulation of type I interferon production|
|B cell receptor signaling pathway|
|organophosphate catabolic process|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|Fc-gamma receptor signaling pathway|
|positive regulation of cation transmembrane transport|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|B cell activation|
|positive regulation of ion transmembrane transport|
|phosphatidylinositol metabolic process|
|regulation of cation channel activity|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|organic hydroxy compound biosynthetic process|
|cellular lipid catabolic process|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|innate immune response-activating signal transduction|
|lymphocyte differentiation|
|Fc receptor signaling pathway|
|phospholipid biosynthetic process|
|regulation of calcium ion transport|
|calcium ion transport|
|activation of innate immune response|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|hemostasis|
|lipid catabolic process|
|divalent inorganic cation transport|
|glycerophospholipid metabolic process|
|response to lipopolysaccharide|
|alcohol metabolic process|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|phagocytosis|
|leukocyte differentiation|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|positive regulation of innate immune response|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of response to biotic stimulus|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|lymphocyte activation|
|regulation of metal ion transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of innate immune response|
|organic hydroxy compound metabolic process|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|hemopoiesis|
|inorganic cation transmembrane transport|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|response to wounding|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of defense response|
|regulation of multi-organism process|
|ion homeostasis|
|cation transport|
|response to lipid|
|positive regulation of immune response|
|organophosphate metabolic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|leukocyte activation|
|ion transmembrane transport|
|cellular lipid metabolic process|
|positive regulation of transport|
|negative regulation of cell death|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|lipid metabolic process|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ion transport|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.26|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.22|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.07|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.03|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.98|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.75|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.73|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.74|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.94|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:btk|BTK]]|0.577|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.499|
|[[:human genes:a:atp13a1|ATP13A1]]|0.466|
|[[:human genes:z:zfand5|ZFAND5]]|0.465|
|[[:human genes:s:smg7|SMG7]]|0.463|
|[[:human genes:p:psmd11|PSMD11]]|0.452|
|[[:human genes:b:blnk|BLNK]]|0.45|
|[[:human genes:r:rps14|RPS14]]|0.45|
|[[:human genes:n:nck1|NCK1]]|0.446|
|[[:human genes:r:rrm1|RRM1]]|0.426|
|[[:human genes:f:fam122a|FAM122A]]|0.416|
|[[:human genes:s:smg1|SMG1]]|0.413|
|[[:human genes:p:psmc2|PSMC2]]|0.4|
|[[:human genes:r:rps28|RPS28]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2407
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCG2 Expression in NALM6 Cells: 7.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>