======= PLD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLD2
  * **<color #00a2e8>Official Name</color>**: phospholipase D2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5338|5338]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14939|O14939]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May have a role in signal-induced cytoskeletal regulation and/or endocytosis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLDc|
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acylphosphatidylethanolamine-specific phospholipase D activity|
|phospholipase D activity|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|synaptic vesicle recycling|
|inositol lipid-mediated signaling|
|phosphatidylinositol binding|
|presynapse|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|Fc receptor signaling pathway|
|phospholipid biosynthetic process|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|small GTPase mediated signal transduction|
|phagocytosis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|organophosphate biosynthetic process|
|immune response-activating signal transduction|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|activation of immune response|
|positive regulation of immune response|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|localization of cell|
|cell motility|
|immune effector process|
|cytoskeleton organization|
|regulation of immune response|
|positive regulation of immune system process|
|lipid metabolic process|
|locomotion|
|movement of cell or subcellular component|
|regulation of immune system process|
|intracellular signal transduction|
|organic substance catabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.32|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.19|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-2.15|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.03|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.01|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.99|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.87|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.83|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.74|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12981
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLD2 Expression in NALM6 Cells: 3.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>