======= PLD6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLD6
  * **<color #00a2e8>Official Name</color>**: phospholipase D family member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=201164|201164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N2A8|Q8N2A8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLD6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLD6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011). {ECO:0000250|UniProtKB:Q5SWZ9, ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397848, ECO:0000269|PubMed:26711011}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiolipin hydrolase activity|
|maternal determination of anterior/posterior axis, embryo|
|P granule organization|
|pole plasm assembly|
|oocyte construction|
|oocyte axis specification|
|oocyte anterior/posterior axis specification|
|positive regulation of mitochondrial fusion|
|regulation of mitochondrial fusion|
|cytoplasm organization|
|tripartite regional subdivision|
|anterior/posterior axis specification, embryo|
|mitochondrial fusion|
|piRNA metabolic process|
|blastoderm segmentation|
|DNA methylation involved in gamete generation|
|embryonic axis specification|
|endonuclease activity|
|oocyte development|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|oocyte differentiation|
|DNA alkylation|
|DNA methylation|
|anterior/posterior axis specification|
|embryonic pattern specification|
|DNA methylation or demethylation|
|oogenesis|
|axis specification|
|DNA modification|
|segmentation|
|organelle fusion|
|positive regulation of mitochondrion organization|
|female gamete generation|
|spermatid development|
|spermatid differentiation|
|cell maturation|
|mitochondrial outer membrane|
|regulation of mitochondrion organization|
|glycerophospholipid biosynthetic process|
|anterior/posterior pattern specification|
|glycerolipid biosynthetic process|
|meiotic cell cycle|
|developmental maturation|
|ribonucleoprotein complex subunit organization|
|phospholipid biosynthetic process|
|macromolecule methylation|
|germ cell development|
|lipid catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|glycerophospholipid metabolic process|
|methylation|
|regionalization|
|cellular process involved in reproduction in multicellular organism|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|pattern specification process|
|mitochondrion organization|
|ncRNA metabolic process|
|organophosphate biosynthetic process|
|spermatogenesis|
|male gamete generation|
|lipid biosynthetic process|
|positive regulation of organelle organization|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|embryo development|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|cell development|
|RNA metabolic process|
|organic substance catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17273
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLD6 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>