======= PLG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLG
  * **<color #00a2e8>Official Name</color>**: plasminogen
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5340|5340]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00747|P00747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
|PAN 1|
|Kringle|
|DUF1986|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interaction with symbiont via secreted substance|
|proteasome core complex binding|
|symbiotic process mediated by secreted substance|
|other organism cell membrane|
|positive regulation of fibrinolysis|
|extrinsic component of external side of plasma membrane|
|protein antigen binding|
|negative regulation of cell-cell adhesion mediated by cadherin|
|negative regulation of fibrinolysis|
|regulation of fibrinolysis|
|apolipoprotein binding|
|regulation of cell-cell adhesion mediated by cadherin|
|fibrinolysis|
|positive regulation of blood coagulation|
|positive regulation of hemostasis|
|positive regulation of coagulation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of wound healing|
|serine-type peptidase activity|
|negative regulation of cell-substrate adhesion|
|positive regulation of response to wounding|
|extracellular matrix disassembly|
|platelet alpha granule lumen|
|negative regulation of wound healing|
|endopeptidase activity|
|interaction with symbiont|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|kinase binding|
|tissue remodeling|
|chaperone binding|
|platelet degranulation|
|regulation of wound healing|
|blood microparticle|
|serine-type endopeptidase activity|
|regulation of response to wounding|
|negative regulation of cell-cell adhesion|
|regulation of cell-substrate adhesion|
|protein domain specific binding|
|negative regulation of cell adhesion|
|blood coagulation|
|coagulation|
|hemostasis|
|signaling receptor binding|
|extracellular matrix organization|
|enzyme binding|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|regulation of cell-cell adhesion|
|cellular component disassembly|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|positive regulation of response to external stimulus|
|cell surface|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulated exocytosis|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|secretion by cell|
|export from cell|
|regulation of response to external stimulus|
|secretion|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of response to stress|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.77|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4387
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLG Expression in NALM6 Cells: 1.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>