======= PLIN5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLIN5
  * **<color #00a2e8>Official Name</color>**: perilipin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440503|440503]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00G26|Q00G26]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLIN5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLIN5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613248|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250, ECO:0000269|PubMed:17234449}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Perilipin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of peroxisome proliferator activated receptor signaling pathway|
|negative regulation of triglyceride catabolic process|
|negative regulation of fatty acid beta-oxidation|
|lipase binding|
|positive regulation of sequestering of triglyceride|
|negative regulation of triglyceride metabolic process|
|negative regulation of fatty acid oxidation|
|positive regulation of fatty acid beta-oxidation|
|regulation of triglyceride catabolic process|
|positive regulation of triglyceride biosynthetic process|
|regulation of sequestering of triglyceride|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|positive regulation of fatty acid oxidation|
|regulation of triglyceride biosynthetic process|
|negative regulation of lipase activity|
|regulation of fatty acid beta-oxidation|
|positive regulation of triglyceride metabolic process|
|lipid droplet organization|
|positive regulation of lipid storage|
|negative regulation of lipid catabolic process|
|positive regulation of lipid catabolic process|
|negative regulation of fatty acid metabolic process|
|lipid storage|
|regulation of fatty acid oxidation|
|positive regulation of fatty acid metabolic process|
|regulation of triglyceride metabolic process|
|regulation of lipid storage|
|mitochondrion localization|
|negative regulation of reactive oxygen species metabolic process|
|regulation of lipid catabolic process|
|positive regulation of lipase activity|
|positive regulation of lipid biosynthetic process|
|positive regulation of lipid localization|
|lipid droplet|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|regulation of lipase activity|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|positive regulation of lipid metabolic process|
|maintenance of location|
|regulation of cellular ketone metabolic process|
|regulation of reactive oxygen species metabolic process|
|regulation of lipid biosynthetic process|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|lipid localization|
|positive regulation of cellular catabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of hydrolase activity|
|organelle localization|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|identical protein binding|
|negative regulation of molecular function|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|negative regulation of response to stimulus|
|positive regulation of molecular function|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7829
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLIN5 Expression in NALM6 Cells: 3.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>