======= PLK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLK3
  * **<color #00a2e8>Official Name</color>**: polo like kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1263|1263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4B4|Q9H4B4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602913|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|POLO box|
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of chaperone-mediated autophagy|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia|
|endomitotic cell cycle|
|Golgi disassembly|
|regulation of chaperone-mediated autophagy|
|organelle inheritance|
|Golgi inheritance|
|Golgi stack|
|protein kinase B signaling|
|cytoplasmic microtubule organization|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|organelle disassembly|
|p53 binding|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|response to osmotic stress|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of cytokinesis|
|mitotic DNA damage checkpoint|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|positive regulation of proteasomal protein catabolic process|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|G1/S transition of mitotic cell cycle|
|signal transduction by p53 class mediator|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of autophagy|
|cell cycle G1/S phase transition|
|spindle pole|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|G2/M transition of mitotic cell cycle|
|Golgi organization|
|DNA damage checkpoint|
|cell cycle G2/M phase transition|
|positive regulation of cellular protein catabolic process|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of intracellular protein transport|
|regulation of cell cycle G1/S phase transition|
|regulation of cell division|
|regulation of signal transduction by p53 class mediator|
|regulation of proteasomal protein catabolic process|
|cellular response to hypoxia|
|cell cycle checkpoint|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|positive regulation of intracellular transport|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|negative regulation of cell cycle phase transition|
|regulation of intracellular protein transport|
|regulation of cellular protein catabolic process|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|regulation of autophagy|
|response to hypoxia|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|neuronal cell body|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of protein catabolic process|
|response to oxidative stress|
|cellular component disassembly|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|dendrite|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|response to radiation|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|protein phosphorylation|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|cell cycle process|
|regulation of protein localization|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLK3 Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>