======= PLN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLN
  * **<color #00a2e8>Official Name</color>**: phospholamban
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5350|5350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26678|P26678]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172405|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. {ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholamban|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium ion-transporting ATPase complex|
|regulation of the force of heart contraction by cardiac conduction|
|negative regulation of calcium ion import into sarcoplasmic reticulum|
|regulation of calcium ion binding|
|negative regulation of calcium ion binding|
|regulation of calcium ion import into sarcoplasmic reticulum|
|negative regulation of ATPase-coupled calcium transmembrane transporter activity|
|adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|ATPase inhibitor activity|
|regulation of relaxation of cardiac muscle|
|G protein-coupled receptor signaling pathway involved in heart process|
|regulation of cardiac muscle cell membrane potential|
|negative regulation of calcium ion import|
|regulation of ATPase-coupled calcium transmembrane transporter activity|
|negative regulation of heart rate|
|regulation of relaxation of muscle|
|relaxation of cardiac muscle|
|negative regulation of ATPase activity|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|relaxation of muscle|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adrenergic receptor signaling pathway|
|negative regulation of heart contraction|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of the force of heart contraction|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|enzyme inhibitor activity|
|sarcoplasmic reticulum membrane|
|negative regulation of blood circulation|
|negative regulation of calcium ion transmembrane transporter activity|
|calcium channel regulator activity|
|response to testosterone|
|regulation of cardiac muscle cell contraction|
|regulation of calcium ion import|
|negative regulation of calcium ion transmembrane transport|
|regulation of actin filament-based movement|
|response to zinc ion|
|negative regulation of calcium ion transport|
|negative regulation of intracellular transport|
|negative regulation of ion transmembrane transporter activity|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|ATPase binding|
|regulation of ATPase activity|
|negative regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|regulation of striated muscle contraction|
|cardiac conduction|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|regulation of heart rate|
|regulation of calcium ion transport into cytosol|
|heart process|
|mitochondrial membrane|
|negative regulation of transmembrane transport|
|regulation of sequestering of calcium ion|
|Notch signaling pathway|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|multicellular organismal signaling|
|vesicle|
|calcium-mediated signaling|
|negative regulation of ion transport|
|cAMP-mediated signaling|
|regulation of calcium ion transmembrane transport|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|negative regulation of binding|
|regulation of cation channel activity|
|cyclic-nucleotide-mediated signaling|
|response to ketone|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to insulin|
|regulation of muscle system process|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|striated muscle tissue development|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle tissue development|
|muscle system process|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|protein homooligomerization|
|regulation of intracellular transport|
|response to metal ion|
|regulation of binding|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|heart development|
|response to inorganic substance|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|negative regulation of catalytic activity|
|cation transport|
|response to lipid|
|circulatory system development|
|protein homodimerization activity|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of cellular component movement|
|response to organonitrogen compound|
|endoplasmic reticulum|
|identical protein binding|
|response to nitrogen compound|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|mitochondrion|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|intracellular signal transduction|
|tissue development|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.29|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.09|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.84|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.72|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.78|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.83|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.85|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.96|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.01|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.03|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.19|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19076
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLN Expression in NALM6 Cells: 0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>