======= PLSCR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLSCR1
  * **<color #00a2e8>Official Name</color>**: phospholipid scramblase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5359|5359]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15162|O15162]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLSCR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLSCR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604170|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Scramblase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylserine biosynthetic process|
|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|CD4 receptor binding|
|regulation of isomerase activity|
|positive regulation of isomerase activity|
|phospholipid scramblase activity|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|plasma membrane phospholipid scrambling|
|response to interferon-beta|
|phosphatidylserine metabolic process|
|epidermal growth factor receptor binding|
|acute-phase response|
|phospholipid translocation|
|lipid translocation|
|regulation of mast cell activation|
|cellular modified amino acid biosynthetic process|
|regulation of membrane lipid distribution|
|positive regulation of ATPase activity|
|negative regulation of viral genome replication|
|acute inflammatory response|
|negative regulation of viral life cycle|
|regulation of ATPase activity|
|phospholipid transport|
|plasma membrane organization|
|regulation of viral genome replication|
|negative regulation of viral process|
|organophosphate ester transport|
|SH3 domain binding|
|platelet activation|
|regulation of viral life cycle|
|defense response to virus|
|cellular modified amino acid metabolic process|
|regulation of viral process|
|glycerophospholipid biosynthetic process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|glycerolipid biosynthetic process|
|membrane raft|
|phospholipid biosynthetic process|
|response to virus|
|blood coagulation|
|coagulation|
|lipid transport|
|hemostasis|
|glycerophospholipid metabolic process|
|lipid localization|
|positive regulation of innate immune response|
|enzyme binding|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|endomembrane system organization|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of innate immune response|
|organic anion transport|
|positive regulation of defense response|
|wound healing|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|organophosphate biosynthetic process|
|response to wounding|
|lipid biosynthetic process|
|anion transport|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|perinuclear region of cytoplasm|
|calcium ion binding|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|membrane organization|
|nucleolus|
|positive regulation of immune response|
|organophosphate metabolic process|
|apoptotic process|
|defense response to other organism|
|cellular lipid metabolic process|
|Golgi apparatus|
|programmed cell death|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|DNA binding|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15194
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLSCR1 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>