======= PLXNA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLXNA3
  * **<color #00a2e8>Official Name</color>**: plexin A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55558|55558]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51805|P51805]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLXNA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLXNA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300022|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Plexin cytopl|
|PSI|
|Sema|
|TIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trigeminal nerve structural organization|
|trigeminal nerve morphogenesis|
|branchiomotor neuron axon guidance|
|pyramidal neuron development|
|pyramidal neuron differentiation|
|facial nerve structural organization|
|cranial nerve structural organization|
|semaphorin receptor complex|
|facial nerve morphogenesis|
|facial nerve development|
|semaphorin-plexin signaling pathway involved in axon guidance|
|trigeminal nerve development|
|semaphorin receptor activity|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|anatomical structure arrangement|
|preganglionic parasympathetic fiber development|
|parasympathetic nervous system development|
|negative regulation of axon extension involved in axon guidance|
|negative regulation of axon guidance|
|motor neuron axon guidance|
|cranial nerve morphogenesis|
|forebrain neuron development|
|regulation of axon extension involved in axon guidance|
|semaphorin-plexin signaling pathway|
|negative regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|autonomic nervous system development|
|forebrain neuron differentiation|
|cranial nerve development|
|negative regulation of chemotaxis|
|neuron projection extension|
|forebrain generation of neurons|
|negative regulation of axonogenesis|
|nerve development|
|central nervous system neuron development|
|hippocampus development|
|positive regulation of axonogenesis|
|developmental cell growth|
|cell growth|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|limbic system development|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|transmembrane signaling receptor activity|
|regulation of cell shape|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|pallium development|
|central nervous system neuron differentiation|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of chemotaxis|
|positive regulation of cytoskeleton organization|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|negative regulation of cell development|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|axonogenesis|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|forebrain development|
|developmental growth|
|growth|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell junction|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.77|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9352
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLXNA3 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>