======= PMPCA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PMPCA
  * **<color #00a2e8>Official Name</color>**: peptidase, mitochondrial processing subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23203|23203]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q10713|Q10713]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PMPCA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PMPCA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves presequences (transit peptides) from mitochondrial protein precursors. {ECO:0000269|PubMed:25808372}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M16|
|Peptidase M16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial processing peptidase complex|
|protein processing involved in protein targeting to mitochondrion|
|mitochondrial protein processing|
|mitochondrial calcium ion transmembrane transport|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|endopeptidase activity|
|protein localization to mitochondrion|
|metalloendopeptidase activity|
|protein processing|
|calcium ion transmembrane transport|
|mitochondrial transport|
|protein maturation|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|protein localization to organelle|
|cation transport|
|ion transmembrane transport|
|intracellular protein transport|
|mitochondrion|
|proteolysis|
|transmembrane transport|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.38|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.3|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.89|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.85|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.77|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.73|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.75|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.76|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.81|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.03|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.16|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.57|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.84|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.455|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 714/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|24/26|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1419
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PMPCA Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>