======= PNN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNN
  * **<color #00a2e8>Official Name</color>**: pinin, desmosome associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5411|5411]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H307|Q9H307]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603154|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pinin SDK memA|
|Pinin SDK N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exon-exon junction complex|
|desmosome|
|catalytic step 2 spliceosome|
|intermediate filament|
|cell-cell junction|
|structural molecule activity|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|cell adhesion|
|biological adhesion|
|RNA binding|
|DNA binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.21|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.85|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.72|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.84|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.88|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.88|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.9|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.28|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 96/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|4/28|
|blood|7/28|
|bone|5/26|
|breast|4/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|4/20|
|lung|5/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNN Expression in NALM6 Cells: 9.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>