======= PNPLA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNPLA8
  * **<color #00a2e8>Official Name</color>**: patatin like phospholipase domain containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50640|50640]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP80|Q9NP80]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNPLA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNPLA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612123|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Patatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylethanolamine catabolic process|
|phosphatidylcholine catabolic process|
|calcium-independent phospholipase A2 activity|
|linoleic acid metabolic process|
|prostanoid biosynthetic process|
|prostaglandin biosynthetic process|
|glycerophospholipid catabolic process|
|lysophospholipase activity|
|phosphatidylethanolamine metabolic process|
|arachidonate transport|
|arachidonic acid secretion|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|icosanoid secretion|
|icosanoid transport|
|fatty acid derivative transport|
|prostanoid metabolic process|
|prostaglandin metabolic process|
|phospholipid catabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|glycerolipid catabolic process|
|peroxisomal membrane|
|arachidonic acid metabolic process|
|long-chain fatty acid transport|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|acid secretion|
|fatty acid derivative biosynthetic process|
|unsaturated fatty acid metabolic process|
|peroxisome|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|organophosphate catabolic process|
|monocarboxylic acid transport|
|fatty acid derivative metabolic process|
|monocarboxylic acid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycerophospholipid metabolic process|
|lipid localization|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic anion transport|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|Golgi membrane|
|perinuclear region of cytoplasm|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|cell death|
|secretion|
|lipid metabolic process|
|ion transport|
|ATP binding|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.83|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.98|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.98|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.04|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.08|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.22|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.23|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.27|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.3|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.46|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:timm23|TIMM23]]|0.427|
|[[:human genes:m:mtx2|MTX2]]|0.423|
|[[:human genes:g:gng11|GNG11]]|0.41|
|[[:human genes:k:kcmf1|KCMF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 778
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNPLA8 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>