======= PODN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PODN
  * **<color #00a2e8>Official Name</color>**: podocan
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=127435|127435]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z5L7|Q7Z5L7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PODN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PODN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Negatively regulates cell proliferation and cell migration. {ECO:0000269|PubMed:15063725}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular matrix structural constituent conferring compression resistance|
|collagen binding|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|collagen-containing extracellular matrix|
|negative regulation of cell population proliferation|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|extracellular space|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.7|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.82|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.83|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PODN Expression in NALM6 Cells: -0.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>