======= POLB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLB
  * **<color #00a2e8>Official Name</color>**: DNA polymerase beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5423|5423]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06746|P06746]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/174760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. {ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9572863}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol lambd f|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immunoglobulin heavy chain V-D-J recombination|
|base-excision repair, base-free sugar-phosphate removal|
|DNA dephosphorylation|
|base-excision repair, DNA ligation|
|immunoglobulin V(D)J recombination|
|base-excision repair, gap-filling|
|DNA ligation involved in DNA repair|
|pyrimidine dimer repair|
|DNA-(apurinic or apyrimidinic site) endonuclease activity|
|DNA ligation|
|lyase activity|
|lymph node development|
|V(D)J recombination|
|somatic hypermutation of immunoglobulin genes|
|somatic diversification of immune receptors via somatic mutation|
|response to hyperoxia|
|somatic recombination of immunoglobulin gene segments|
|nucleotide-excision repair, DNA gap filling|
|DNA-directed DNA polymerase activity|
|response to increased oxygen levels|
|salivary gland morphogenesis|
|salivary gland development|
|spleen development|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|somatic diversification of immunoglobulins|
|spindle microtubule|
|base-excision repair|
|exocrine system development|
|neuron apoptotic process|
|somatic diversification of immune receptors|
|neuron death|
|damaged DNA binding|
|response to gamma radiation|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|gland morphogenesis|
|DNA biosynthetic process|
|nucleotide-excision repair|
|DNA-dependent DNA replication|
|response to ethanol|
|intrinsic apoptotic signaling pathway|
|response to ionizing radiation|
|immunoglobulin production|
|production of molecular mediator of immune response|
|double-strand break repair|
|homeostasis of number of cells|
|DNA replication|
|DNA recombination|
|response to alcohol|
|microtubule binding|
|aging|
|protein deubiquitination|
|apoptotic signaling pathway|
|protein modification by small protein removal|
|response to antibiotic|
|dephosphorylation|
|microtubule|
|enzyme binding|
|in utero embryonic development|
|response to oxygen levels|
|gland development|
|response to radiation|
|inflammatory response|
|response to toxic substance|
|DNA repair|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|apoptotic process|
|animal organ morphogenesis|
|embryo development|
|protein modification by small protein conjugation or removal|
|response to drug|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|proteolysis|
|organic cyclic compound biosynthetic process|
|defense response|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.55|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-3.21|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.14|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.8|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.7|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.73|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18983
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLB Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>