======= POLE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLE
  * **<color #00a2e8>Official Name</color>**: DNA polymerase epsilon, catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5426|5426]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07864|Q07864]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/174762|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in DNA repair and in chromosomal DNA replication.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol B exo2|
|DNA pol B|
|DUF1744|
|DNA pol B exo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication proofreading|
|leading strand elongation|
|epsilon DNA polymerase complex|
|base-excision repair, gap-filling|
|single-stranded DNA 3-5 exodeoxyribonuclease activity|
|DNA strand elongation involved in DNA replication|
|DNA strand elongation|
|nucleotide-excision repair, DNA gap filling|
|telomere maintenance via semi-conservative replication|
|DNA-directed DNA polymerase activity|
|DNA replication initiation|
|base-excision repair|
|DNA-dependent DNA replication maintenance of fidelity|
|4 iron, 4 sulfur cluster binding|
|nuclear DNA replication|
|cell cycle DNA replication|
|DNA synthesis involved in DNA repair|
|nucleotide binding|
|telomere maintenance|
|telomere organization|
|DNA biosynthetic process|
|nucleotide-excision repair|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|DNA replication|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|chromatin binding|
|embryonic organ development|
|DNA repair|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|cellular homeostasis|
|embryo development|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.53|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.38|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.34|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.08|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.95|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.9|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.9|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.89|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.86|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.85|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.85|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.8|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.73|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.73|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.73|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.77|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.78|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.79|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.83|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.84|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.85|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.86|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.97|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.98|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.98|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.04|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|2.05|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.14|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.19|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.19|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.2|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.21|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.26|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.3|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.32|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.36|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.41|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.44|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.5|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.56|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.79|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd3|PSMD3]]|0.566|
|[[:human genes:c:chd4|CHD4]]|0.562|
|[[:human genes:p:psmb2|PSMB2]]|0.548|
|[[:human genes:p:prim1|PRIM1]]|0.54|
|[[:human genes:t:tceb3c|TCEB3C]]|0.537|
|[[:human genes:p:psmb4|PSMB4]]|0.527|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.526|
|[[:human genes:p:pan3|PAN3]]|0.519|
|[[:human genes:n:nupl1|NUPL1]]|0.518|
|[[:human genes:p:psma6|PSMA6]]|0.511|
|[[:human genes:p:polr2j3|POLR2J3]]|0.51|
|[[:human genes:p:psmd2|PSMD2]]|0.508|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.507|
|[[:human genes:n:nup160|NUP160]]|0.507|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.505|
|[[:human genes:s:supt5h|SUPT5H]]|0.505|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.504|
|[[:human genes:s:slc4a1|SLC4A1]]|0.503|
|[[:human genes:s:sart1|SART1]]|0.503|
|[[:human genes:r:rpl35|RPL35]]|0.502|
|[[:human genes:p:psma7|PSMA7]]|0.501|
|[[:human genes:c:cbwd6|CBWD6]]|0.501|
|[[:human genes:p:psmd7|PSMD7]]|0.5|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.499|
|[[:human genes:p:psmd1|PSMD1]]|0.498|
|[[:human genes:c:cbwd5|CBWD5]]|0.497|
|[[:human genes:c:cdca3|CDCA3]]|0.496|
|[[:human genes:d:dock6|DOCK6]]|0.494|
|[[:human genes:a:aatf|AATF]]|0.493|
|[[:human genes:r:rad51|RAD51]]|0.491|
|[[:human genes:c:cbwd3|CBWD3]]|0.491|
|[[:human genes:c:ccna2|CCNA2]]|0.491|
|[[:human genes:r:rrp15|RRP15]]|0.489|
|[[:human genes:m:mdm2|MDM2]]|0.488|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.487|
|[[:human genes:c:cope|COPE]]|0.484|
|[[:human genes:n:nhp2l1|NHP2L1]]|0.484|
|[[:human genes:n:npipb5|NPIPB5]]|0.483|
|[[:human genes:z:znf830|ZNF830]]|0.482|
|[[:human genes:o:orc6|ORC6]]|0.481|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.48|
|[[:human genes:r:rps2|RPS2]]|0.48|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.48|
|[[:human genes:u:upf1|UPF1]]|0.479|
|[[:human genes:c:cdc45|CDC45]]|0.477|
|[[:human genes:t:ticrr|TICRR]]|0.476|
|[[:human genes:p:psmd11|PSMD11]]|0.476|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.475|
|[[:human genes:m:mt1e|MT1E]]|0.474|
|[[:human genes:k:kctd17|KCTD17]]|0.473|
|[[:human genes:i:ik|IK]]|0.472|
|[[:human genes:a:aamp|AAMP]]|0.472|
|[[:human genes:p:paf1|PAF1]]|0.471|
|[[:human genes:o:orc1|ORC1]]|0.471|
|[[:human genes:r:rrp7a|RRP7A]]|0.471|
|[[:human genes:p:pwp2|PWP2]]|0.47|
|[[:human genes:d:dtl|DTL]]|0.47|
|[[:human genes:g:golga6a|GOLGA6A]]|0.469|
|[[:human genes:c:col2a1|COL2A1]]|0.467|
|[[:human genes:w:wdr75|WDR75]]|0.467|
|[[:human genes:o:osbp|OSBP]]|0.466|
|[[:human genes:p:polr2f|POLR2F]]|0.466|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.464|
|[[:human genes:s:snrpa1|SNRPA1]]|0.463|
|[[:human genes:k:krt78|KRT78]]|0.463|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.462|
|[[:human genes:i:igfn1|IGFN1]]|0.461|
|[[:human genes:c:cgb2|CGB2]]|0.461|
|[[:human genes:l:lad1|LAD1]]|0.459|
|[[:human genes:t:tyms|TYMS]]|0.458|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.455|
|[[:human genes:n:narfl|NARFL]]|0.454|
|[[:human genes:c:c14orf93|C14orf93]]|0.453|
|[[:human genes:s:stil|STIL]]|0.452|
|[[:human genes:i:iscu|ISCU]]|0.45|
|[[:human genes:p:psmc1|PSMC1]]|0.449|
|[[:human genes:t:tsg101|TSG101]]|0.449|
|[[:human genes:r:rps9|RPS9]]|0.448|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.448|
|[[:human genes:r:rad21|RAD21]]|0.448|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.448|
|[[:human genes:l:lrr1|LRR1]]|0.448|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.447|
|[[:human genes:c:chaf1a|CHAF1A]]|0.447|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.447|
|[[:human genes:r:rrp1|RRP1]]|0.446|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.446|
|[[:human genes:t:tfip11|TFIP11]]|0.445|
|[[:human genes:t:timeless|TIMELESS]]|0.445|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.444|
|[[:human genes:c:copb1|COPB1]]|0.443|
|[[:human genes:b:bysl|BYSL]]|0.442|
|[[:human genes:m:mcoln1|MCOLN1]]|0.442|
|[[:human genes:g:golga8o|GOLGA8O]]|0.442|
|[[:human genes:n:napa|NAPA]]|0.441|
|[[:human genes:c:copg1|COPG1]]|0.441|
|[[:human genes:w:wdr43|WDR43]]|0.441|
|[[:human genes:r:rps4x|RPS4X]]|0.44|
|[[:human genes:p:psmc2|PSMC2]]|0.44|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.44|
|[[:human genes:a:acsf2|ACSF2]]|0.44|
|[[:human genes:s:sap30bp|SAP30BP]]|0.44|
|[[:human genes:z:zfand5|ZFAND5]]|0.439|
|[[:human genes:d:ddtl|DDTL]]|0.439|
|[[:human genes:g:gid4|GID4]]|0.439|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.437|
|[[:human genes:r:rps12|RPS12]]|0.437|
|[[:human genes:e:exosc5|EXOSC5]]|0.436|
|[[:human genes:c:copb2|COPB2]]|0.436|
|[[:human genes:e:exosc9|EXOSC9]]|0.435|
|[[:human genes:s:s1pr4|S1PR4]]|0.434|
|[[:human genes:i:incenp|INCENP]]|0.434|
|[[:human genes:x:xylt2|XYLT2]]|0.434|
|[[:human genes:c:cdc73|CDC73]]|0.433|
|[[:human genes:v:vasn|VASN]]|0.433|
|[[:human genes:s:sf3a1|SF3A1]]|0.433|
|[[:human genes:c:c3orf17|C3orf17]]|0.433|
|[[:human genes:f:fam231c|FAM231C]]|0.432|
|[[:human genes:p:psmc6|PSMC6]]|0.431|
|[[:human genes:n:nup205|NUP205]]|0.431|
|[[:human genes:f:fam231a|FAM231A]]|0.431|
|[[:human genes:s:slc6a17|SLC6A17]]|0.431|
|[[:human genes:t:tspy8|TSPY8]]|0.431|
|[[:human genes:p:parp3|PARP3]]|0.429|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.429|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.429|
|[[:human genes:a:atp13a1|ATP13A1]]|0.429|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.428|
|[[:human genes:n:nfatc4|NFATC4]]|0.428|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.428|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.427|
|[[:human genes:r:riok2|RIOK2]]|0.427|
|[[:human genes:g:gpx4|GPX4]]|0.426|
|[[:human genes:d:ddx56|DDX56]]|0.426|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.424|
|[[:human genes:p:pola1|POLA1]]|0.424|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.424|
|[[:human genes:m:mms22l|MMS22L]]|0.424|
|[[:human genes:n:nol10|NOL10]]|0.424|
|[[:human genes:n:npipb11|NPIPB11]]|0.423|
|[[:human genes:n:nop16|NOP16]]|0.423|
|[[:human genes:n:nup153|NUP153]]|0.423|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.423|
|[[:human genes:z:znf574|ZNF574]]|0.423|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.423|
|[[:human genes:a:aqr|AQR]]|0.423|
|[[:human genes:u:uqcrh|UQCRH]]|0.422|
|[[:human genes:c:chchd3|CHCHD3]]|0.421|
|[[:human genes:c:ckap5|CKAP5]]|0.42|
|[[:human genes:d:disp2|DISP2]]|0.42|
|[[:human genes:p:ppfia4|PPFIA4]]|0.42|
|[[:human genes:c:cactin|CACTIN]]|0.42|
|[[:human genes:s:ssh2|SSH2]]|0.419|
|[[:human genes:v:vps28|VPS28]]|0.419|
|[[:human genes:r:rpsa|RPSA]]|0.419|
|[[:human genes:n:nol12|NOL12]]|0.419|
|[[:human genes:e:exosc6|EXOSC6]]|0.419|
|[[:human genes:u:utp20|UTP20]]|0.418|
|[[:human genes:c:cacna1a|CACNA1A]]|0.418|
|[[:human genes:t:twistnb|TWISTNB]]|0.418|
|[[:human genes:c:crocc|CROCC]]|0.417|
|[[:human genes:p:pdcd11|PDCD11]]|0.417|
|[[:human genes:c:cdc6|CDC6]]|0.417|
|[[:human genes:p:psmb1|PSMB1]]|0.416|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.416|
|[[:human genes:f:ftsj3|FTSJ3]]|0.416|
|[[:human genes:m:mylk3|MYLK3]]|0.416|
|[[:human genes:k:kiaa1211|KIAA1211]]|0.415|
|[[:human genes:i:ints5|INTS5]]|0.415|
|[[:human genes:z:znf687|ZNF687]]|0.415|
|[[:human genes:b:bage2|BAGE2]]|0.414|
|[[:human genes:a:ankle2|ANKLE2]]|0.414|
|[[:human genes:b:bage|BAGE]]|0.414|
|[[:human genes:p:pno1|PNO1]]|0.414|
|[[:human genes:f:fam25b|FAM25B]]|0.414|
|[[:human genes:b:bage3|BAGE3]]|0.414|
|[[:human genes:h:hivep3|HIVEP3]]|0.413|
|[[:human genes:a:adrm1|ADRM1]]|0.413|
|[[:human genes:b:bage4|BAGE4]]|0.413|
|[[:human genes:b:bage5|BAGE5]]|0.413|
|[[:human genes:u:utp3|UTP3]]|0.413|
|[[:human genes:r:rrn3|RRN3]]|0.412|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.412|
|[[:human genes:p:psmd8|PSMD8]]|0.412|
|[[:human genes:d:dhx38|DHX38]]|0.412|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.412|
|[[:human genes:a:akirin2|AKIRIN2]]|0.411|
|[[:human genes:m:myt1l|MYT1L]]|0.411|
|[[:human genes:z:znf541|ZNF541]]|0.411|
|[[:human genes:x:xab2|XAB2]]|0.411|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.409|
|[[:human genes:s:smg1|SMG1]]|0.409|
|[[:human genes:w:wdr46|WDR46]]|0.409|
|[[:human genes:d:dnm2|DNM2]]|0.409|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.409|
|[[:human genes:p:pan2|PAN2]]|0.408|
|[[:human genes:c:cebpz|CEBPZ]]|0.408|
|[[:human genes:z:znf655|ZNF655]]|0.408|
|[[:human genes:p:plekha4|PLEKHA4]]|0.408|
|[[:human genes:p:psmc5|PSMC5]]|0.407|
|[[:human genes:r:rps5|RPS5]]|0.407|
|[[:human genes:r:rps3|RPS3]]|0.406|
|[[:human genes:c:cdh24|CDH24]]|0.406|
|[[:human genes:d:ddx21|DDX21]]|0.405|
|[[:human genes:a:acd|ACD]]|0.405|
|[[:human genes:r:ranbp2|RANBP2]]|0.404|
|[[:human genes:m:myh7b|MYH7B]]|0.404|
|[[:human genes:s:scmh1|SCMH1]]|0.403|
|[[:human genes:f:fbxw9|FBXW9]]|0.403|
|[[:human genes:n:npipb8|NPIPB8]]|0.402|
|[[:human genes:m:myo18a|MYO18A]]|0.402|
|[[:human genes:a:ahctf1|AHCTF1]]|0.401|
|[[:human genes:p:pola2|POLA2]]|0.4|
|[[:human genes:p:pigs|PIGS]]|0.4|
|[[:human genes:p:polr2l|POLR2L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 735/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 434
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLE Expression in NALM6 Cells: 8.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>