======= POLR3C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR3C
  * **<color #00a2e8>Official Name</color>**: RNA polymerase III subunit C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10623|10623]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUI4|Q9BUI4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR3C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR3C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617454|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21358628}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HTH 9|
|RNA pol Rpc82|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase III activity|
|RNA polymerase III complex|
|regulation of transcription by RNA polymerase III|
|positive regulation of interferon-beta production|
|DNA-directed 5-3 RNA polymerase activity|
|transcription by RNA polymerase III|
|regulation of interferon-beta production|
|positive regulation of type I interferon production|
|single-stranded DNA binding|
|regulation of type I interferon production|
|defense response to virus|
|response to virus|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|defense response to other organism|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.8|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.86|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.89|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.98|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.99|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.12|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.36|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.38|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.62|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr3h|POLR3H]]|0.498|
|[[:human genes:d:dpagt1|DPAGT1]]|0.495|
|[[:human genes:p:pmm2|PMM2]]|0.447|
|[[:human genes:m:mbtps2|MBTPS2]]|0.447|
|[[:human genes:t:thg1l|THG1L]]|0.444|
|[[:human genes:a:alg6|ALG6]]|0.444|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.436|
|[[:human genes:a:alg1|ALG1]]|0.432|
|[[:human genes:r:rnmt|RNMT]]|0.432|
|[[:human genes:t:tti1|TTI1]]|0.43|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.426|
|[[:human genes:s:srp68|SRP68]]|0.423|
|[[:human genes:h:hmgb2|HMGB2]]|0.422|
|[[:human genes:v:vmp1|VMP1]]|0.41|
|[[:human genes:e:eef1e1|EEF1E1]]|0.409|
|[[:human genes:d:dnajc3|DNAJC3]]|0.406|
|[[:human genes:t:tpk1|TPK1]]|0.406|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 203/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|8/28|
|bone|11/25|
|breast|6/33|
|central nervous system|24/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|5/15|
|kidney|3/21|
|liver|5/20|
|lung|20/75|
|lymphocyte|2/14|
|ovary|8/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|11/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 262
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR3C Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>