======= POMC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POMC
  * **<color #00a2e8>Official Name</color>**: proopiomelanocortin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5443|5443]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01189|P01189]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POMC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POMC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Met-enkephalin: Endogenous opiate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Op neuropeptide|
|ACTH domain|
|NPP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 1 melanocortin receptor binding|
|type 4 melanocortin receptor binding|
|type 3 melanocortin receptor binding|
|regulation of corticosterone secretion|
|regulation of glucocorticoid secretion|
|regulation of corticosteroid hormone secretion|
|regulation of steroid hormone secretion|
|regulation of appetite|
|regulation of glycogen metabolic process|
|regulation of polysaccharide metabolic process|
|regulation of endocrine process|
|cellular pigmentation|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|G protein-coupled receptor binding|
|secretory granule|
|pigmentation|
|hormone activity|
|neuropeptide signaling pathway|
|regulation of lipid transport|
|regulation of glucose metabolic process|
|secretory granule lumen|
|regulation of lipid localization|
|regulation of cellular carbohydrate metabolic process|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of generation of precursor metabolites and energy|
|regulation of blood pressure|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of carbohydrate metabolic process|
|regulation of hormone secretion|
|negative regulation of cytokine production|
|signaling receptor binding|
|blood circulation|
|circulatory system process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|regulation of system process|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of secretion by cell|
|regulation of secretion|
|cellular response to cytokine stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|G protein-coupled receptor signaling pathway|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.82|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.93|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POMC Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>