======= POU4F1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POU4F1
  * **<color #00a2e8>Official Name</color>**: POU class 4 homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5457|5457]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01851|Q01851]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POU4F1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POU4F1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601632|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site. {ECO:0000250|UniProtKB:P17208}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|Pou|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proprioception involved in equilibrioception|
|regulation of transcription elongation from RNA polymerase I promoter|
|negative regulation of transcription elongation by RNA polymerase I|
|habenula development|
|epithalamus development|
|negative regulation of transcription by RNA polymerase I|
|proprioception|
|equilibrioception|
|ventricular compact myocardium morphogenesis|
|trigeminal nerve development|
|peripheral nervous system neuron differentiation|
|peripheral nervous system neuron development|
|suckling behavior|
|negative regulation of DNA-templated transcription, elongation|
|cell migration in hindbrain|
|neuromuscular process controlling posture|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of osteoclast differentiation|
|innervation|
|regulation of transcription by RNA polymerase I|
|neuron fate specification|
|GTPase binding|
|cellular response to estradiol stimulus|
|ventricular cardiac muscle tissue morphogenesis|
|regulation of DNA-templated transcription, elongation|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|cranial nerve development|
|neuromuscular process controlling balance|
|regulation of transcription regulatory region DNA binding|
|positive regulation of myeloid leukocyte differentiation|
|ventricular cardiac muscle tissue development|
|positive regulation of DNA binding|
|neuron fate commitment|
|regulation of osteoclast differentiation|
|multi-organism behavior|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|peripheral nervous system development|
|diencephalon development|
|nerve development|
|positive regulation of cell cycle arrest|
|muscle tissue morphogenesis|
|feeding behavior|
|muscle organ morphogenesis|
|cell fate specification|
|positive regulation of myeloid cell differentiation|
|synapse assembly|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of cell cycle arrest|
|neuromuscular process|
|single-stranded DNA binding|
|regulation of myeloid leukocyte differentiation|
|signal transduction by p53 class mediator|
|mesoderm development|
|regulation of DNA binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|response to estradiol|
|negative regulation of neuron apoptotic process|
|positive regulation of leukocyte differentiation|
|intrinsic apoptotic signaling pathway|
|hindbrain development|
|cardiac muscle tissue development|
|cardiac chamber development|
|positive regulation of binding|
|central nervous system neuron differentiation|
|regulation of signal transduction by p53 class mediator|
|positive regulation of hemopoiesis|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of myeloid cell differentiation|
|nuclear chromatin|
|transcription corepressor activity|
|cell fate commitment|
|heart morphogenesis|
|synapse organization|
|regulation of leukocyte differentiation|
|apoptotic signaling pathway|
|transcription coactivator activity|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|muscle organ development|
|muscle tissue development|
|regulation of neuron death|
|neuron projection|
|sensory system development|
|axonogenesis|
|positive regulation of cell cycle|
|regulation of binding|
|forebrain development|
|chromatin binding|
|axon development|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|muscle structure development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|cellular response to lipid|
|heart development|
|cellular response to organic cyclic compound|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|behavior|
|cellular response to hormone stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|neuron projection development|
|positive regulation of cell death|
|cell morphogenesis|
|brain development|
|regulation of cell cycle process|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|central nervous system development|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|neuron differentiation|
|programmed cell death|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|cell death|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17772
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POU4F1 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>