======= PPARA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPARA
  * **<color #00a2e8>Official Name</color>**: peroxisome proliferator activated receptor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5465|5465]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07869|Q07869]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPARA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPARA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/170998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter|
|regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter|
|regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter|
|regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter|
|regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter|
|regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter|
|regulation of lipid transport by regulation of transcription from RNA polymerase II promoter|
|NFAT protein binding|
|negative regulation of sequestering of triglyceride|
|negative regulation of receptor biosynthetic process|
|behavioral response to nicotine|
|MDM2/MDM4 family protein binding|
|negative regulation of cholesterol storage|
|positive regulation of fatty acid beta-oxidation|
|negative regulation of cell growth involved in cardiac muscle cell development|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|enamel mineralization|
|regulation of sequestering of triglyceride|
|negative regulation of pri-miRNA transcription by RNA polymerase II|
|negative regulation of response to food|
|negative regulation of macrophage derived foam cell differentiation|
|positive regulation of gluconeogenesis|
|negative regulation of glycolytic process|
|negative regulation of appetite|
|negative regulation of response to nutrient levels|
|regulation of cholesterol storage|
|negative regulation of response to extracellular stimulus|
|tooth mineralization|
|positive regulation of fatty acid oxidation|
|negative regulation of cardiac muscle cell differentiation|
|regulation of fatty acid beta-oxidation|
|regulation of cell growth involved in cardiac muscle cell development|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|regulation of response to food|
|negative regulation of lipid storage|
|transcription coactivator binding|
|negative regulation of cardiocyte differentiation|
|amelogenesis|
|regulation of receptor biosynthetic process|
|negative regulation of cardiac muscle tissue growth|
|negative regulation of heart growth|
|regulation of appetite|
|fatty acid binding|
|positive regulation of lipid catabolic process|
|regulation of response to extracellular stimulus|
|regulation of response to nutrient levels|
|negative regulation of ATP metabolic process|
|negative regulation of cardiac muscle hypertrophy|
|negative regulation of muscle hypertrophy|
|regulation of macrophage derived foam cell differentiation|
|regulation of fatty acid oxidation|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|ubiquitin conjugating enzyme binding|
|positive regulation of fatty acid metabolic process|
|RNA polymerase II repressing transcription factor binding|
|regulation of cardiac muscle cell differentiation|
|negative regulation of striated muscle cell differentiation|
|positive regulation of glucose metabolic process|
|negative regulation of lipid localization|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of pri-miRNA transcription by RNA polymerase II|
|regulation of lipid storage|
|regulation of gluconeogenesis|
|negative regulation of blood pressure|
|nuclear receptor activity|
|negative regulation of carbohydrate metabolic process|
|negative regulation of striated muscle tissue development|
|phosphatase binding|
|negative regulation of muscle organ development|
|response to nicotine|
|regulation of cardiocyte differentiation|
|negative regulation of muscle tissue development|
|steroid hormone receptor activity|
|regulation of lipid catabolic process|
|negative regulation of muscle cell differentiation|
|regulation of cardiac muscle hypertrophy|
|drug binding|
|regulation of cardiac muscle tissue growth|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of muscle hypertrophy|
|circadian regulation of gene expression|
|regulation of heart growth|
|nuclear receptor transcription coactivator activity|
|RNA polymerase II transcription factor complex|
|fatty acid transport|
|transcription regulatory region sequence-specific DNA binding|
|regulation of cardiac muscle tissue development|
|positive regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|odontogenesis of dentin-containing tooth|
|regulation of muscle adaptation|
|regulation of fatty acid metabolic process|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|biomineralization|
|biomineral tissue development|
|regulation of organ growth|
|regulation of carbohydrate biosynthetic process|
|regulation of striated muscle cell differentiation|
|negative regulation of protein binding|
|negative regulation of developmental growth|
|regulation of lipid transport|
|regulation of glucose metabolic process|
|regulation of circadian rhythm|
|regulation of purine nucleotide metabolic process|
|lipoprotein metabolic process|
|regulation of nucleotide metabolic process|
|steroid hormone mediated signaling pathway|
|odontogenesis|
|regulation of ATP metabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of inflammatory response|
|monocarboxylic acid transport|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of lipid metabolic process|
|circadian rhythm|
|adult behavior|
|regulation of muscle cell differentiation|
|lipid binding|
|regulation of generation of precursor metabolites and energy|
|intracellular receptor signaling pathway|
|negative regulation of binding|
|hormone-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|negative regulation of cell-cell adhesion|
|transcription initiation from RNA polymerase II promoter|
|regulation of blood pressure|
|negative regulation of cell growth|
|cellular response to steroid hormone stimulus|
|regulation of carbohydrate metabolic process|
|signaling receptor activity|
|negative regulation of neuron death|
|negative regulation of defense response|
|DNA-templated transcription, initiation|
|regulation of protein binding|
|response to insulin|
|regulation of muscle system process|
|negative regulation of growth|
|protein domain specific binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|protein-containing complex binding|
|negative regulation of cell adhesion|
|rhythmic process|
|organic acid transport|
|carboxylic acid transport|
|regulation of leukocyte cell-cell adhesion|
|lipid transport|
|negative regulation of catabolic process|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|lipid localization|
|fatty acid metabolic process|
|response to steroid hormone|
|regulation of developmental growth|
|transcription factor binding|
|negative regulation of cell development|
|regulation of inflammatory response|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|negative regulation of response to external stimulus|
|regulation of binding|
|response to oxygen levels|
|blood circulation|
|response to peptide hormone|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of cell-cell adhesion|
|epidermis development|
|regulation of cell growth|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|organic anion transport|
|response to peptide|
|wound healing|
|transcription by RNA polymerase II|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|cellular response to lipid|
|heart development|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|behavior|
|anion transport|
|regulation of system process|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of growth|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|regulation of defense response|
|regulation of cellular catabolic process|
|zinc ion binding|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10278
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPARA Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>