======= PPFIA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPFIA1
  * **<color #00a2e8>Official Name</color>**: PTPRF interacting protein alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8500|8500]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13136|Q13136]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPFIA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPFIA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611054|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
|SAM 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of stress fiber assembly|
|negative regulation of protein localization to plasma membrane|
|negative regulation of actin filament bundle assembly|
|negative regulation of protein localization to cell periphery|
|glutamate secretion|
|negative regulation of protein localization to membrane|
|presynaptic active zone|
|acidic amino acid transport|
|dicarboxylic acid transport|
|regulation of stress fiber assembly|
|acid secretion|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of protein localization to plasma membrane|
|neurotransmitter secretion|
|signal release from synapse|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|amino acid transport|
|cell-matrix adhesion|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|signal release|
|neurotransmitter transport|
|cell-substrate adhesion|
|regulation of protein localization to membrane|
|regulation of actin filament organization|
|organic acid transport|
|carboxylic acid transport|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|focal adhesion|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|anion transport|
|negative regulation of cellular component organization|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell-cell signaling|
|secretion|
|regulation of organelle organization|
|ion transport|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.85|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14847
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPFIA1 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>