======= PPIA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIA
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5478|5478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62937|P62937]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uncoating of virus|
|exit from host cell|
|movement in host environment|
|movement in environment of other organism involved in symbiotic interaction|
|exit from host|
|viral release from host cell|
|membrane fusion involved in viral entry into host cell|
|fusion of virus membrane with host plasma membrane|
|multi-organism membrane fusion|
|establishment of integrated proviral latency|
|establishment of viral latency|
|multi-organism membrane organization|
|virion binding|
|viral latency|
|lipid droplet organization|
|multi-organism cellular process|
|cyclosporin A binding|
|positive regulation of viral genome replication|
|RNA-dependent DNA biosynthetic process|
|protein refolding|
|virion assembly|
|protein peptidyl-prolyl isomerization|
|interleukin-12-mediated signaling pathway|
|peptidyl-prolyl cis-trans isomerase activity|
|cellular response to interleukin-12|
|response to interleukin-12|
|peptidyl-proline modification|
|positive regulation of viral life cycle|
|regulation of viral genome replication|
|viral entry into host cell|
|entry into host cell|
|entry into host|
|positive regulation of viral process|
|DNA biosynthetic process|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|membrane fusion|
|unfolded protein binding|
|vesicle|
|regulation of viral life cycle|
|interaction with host|
|viral life cycle|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein folding|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|leukocyte migration|
|positive regulation of secretion by cell|
|focal adhesion|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|protein-containing complex|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cytokine-mediated signaling pathway|
|viral process|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|regulation of secretion|
|interspecies interaction between organisms|
|membrane organization|
|peptidyl-amino acid modification|
|leukocyte activation|
|cell migration|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|RNA binding|
|movement of cell or subcellular component|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.03|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|2/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4234
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIA Expression in NALM6 Cells: 9.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>