======= PPIP5K2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIP5K2
  * **<color #00a2e8>Official Name</color>**: diphosphoinositol pentakisphosphate kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23262|23262]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43314|O43314]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIP5K2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIP5K2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611648|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|His Phos 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diphosphoinositol-pentakisphosphate kinase activity|
|5-diphosphoinositol pentakisphosphate 3-kinase activity|
|inositol heptakisphosphate kinase activity|
|inositol-1,3,4,5,6-pentakisphosphate kinase activity|
|inositol hexakisphosphate 1-kinase activity|
|inositol hexakisphosphate 3-kinase activity|
|inositol hexakisphosphate 5-kinase activity|
|inositol hexakisphosphate kinase activity|
|inositol metabolic process|
|inositol phosphate biosynthetic process|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|cellular carbohydrate metabolic process|
|organic hydroxy compound biosynthetic process|
|alcohol metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|phosphorylation|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.78|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.51|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.96|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.81|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.71|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.73|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.81|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.84|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.97|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.01|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.1|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.24|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.58|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nudt11|NUDT11]]|0.487|
|[[:human genes:n:nudt10|NUDT10]]|0.455|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8023
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIP5K2 Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>