======= PPM1G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPM1G
  * **<color #00a2e8>Official Name</color>**: protein phosphatase, Mg2+/Mn2+ dependent 1G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5496|5496]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15355|O15355]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPM1G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPM1G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605119|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP2C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-threonine dephosphorylation|
|magnesium-dependent protein serine/threonine phosphatase activity|
|protein serine/threonine phosphatase activity|
|cell cycle arrest|
|protein dephosphorylation|
|dephosphorylation|
|negative regulation of cell cycle|
|cell cycle process|
|regulation of cell cycle|
|cell cycle|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.32|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.26|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.84|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.02|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.17|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|4.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.418|
|[[:human genes:u:utp6|UTP6]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5380
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPM1G Expression in NALM6 Cells: 7.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>