======= PPP1CB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1CB
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 catalytic subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5500|5500]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62140|P62140]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1CB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1CB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin-light-chain-phosphatase activity|
|myosin phosphatase activity|
|regulation of glycogen catabolic process|
|glycogen granule|
|PTW/PP1 phosphatase complex|
|regulation of cellular carbohydrate catabolic process|
|protein phosphatase type 1 complex|
|entrainment of circadian clock by photoperiod|
|photoperiodism|
|entrainment of circadian clock|
|regulation of glucan biosynthetic process|
|regulation of glycogen biosynthetic process|
|regulation of glycogen metabolic process|
|regulation of polysaccharide biosynthetic process|
|regulation of polysaccharide metabolic process|
|phosphatase activity|
|glycogen metabolic process|
|glucan metabolic process|
|cellular glucan metabolic process|
|circadian regulation of gene expression|
|energy reserve metabolic process|
|protein serine/threonine phosphatase activity|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|regulation of carbohydrate catabolic process|
|regulation of carbohydrate biosynthetic process|
|nuclear chromosome, telomeric region|
|regulation of glucose metabolic process|
|regulation of circadian rhythm|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|regulation of cellular carbohydrate metabolic process|
|circadian rhythm|
|regulation of generation of precursor metabolites and energy|
|cellular carbohydrate metabolic process|
|regulation of carbohydrate metabolic process|
|protein dephosphorylation|
|energy derivation by oxidation of organic compounds|
|mitotic cell cycle phase transition|
|rhythmic process|
|cell cycle phase transition|
|response to light stimulus|
|dephosphorylation|
|focal adhesion|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|response to radiation|
|protein kinase binding|
|carbohydrate metabolic process|
|cell division|
|mitotic cell cycle process|
|regulation of cell adhesion|
|mitotic cell cycle|
|regulation of cellular catabolic process|
|nucleolus|
|oxidation-reduction process|
|regulation of catabolic process|
|cell cycle process|
|response to abiotic stimulus|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.3|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.11|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.09|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.92|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.88|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.86|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.85|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.82|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|2/28|
|bone|2/25|
|breast|2/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|1/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 844
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1CB Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>