======= PPP1R10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R10
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5514|5514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QC0|Q96QC0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603771|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). {ECO:0000250, ECO:0000269|PubMed:9450550}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med26|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitotic DNA damage checkpoint|
|regulation of mitotic DNA damage checkpoint|
|negative regulation of DNA damage checkpoint|
|negative regulation of cell cycle checkpoint|
|PTW/PP1 phosphatase complex|
|regulation of DNA damage checkpoint|
|negative regulation of cardiac muscle cell apoptotic process|
|negative regulation of striated muscle cell apoptotic process|
|regulation of cell cycle checkpoint|
|protein phosphatase inhibitor activity|
|regulation of cardiac muscle cell apoptotic process|
|negative regulation of muscle cell apoptotic process|
|regulation of striated muscle cell apoptotic process|
|positive regulation of telomere maintenance|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|regulation of muscle cell apoptotic process|
|negative regulation of response to DNA damage stimulus|
|regulation of telomere maintenance|
|protein import into nucleus|
|negative regulation of phosphatase activity|
|nuclear chromosome, telomeric region|
|negative regulation of dephosphorylation|
|chromatin|
|import into nucleus|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|protein import|
|positive regulation of mitotic cell cycle|
|protein localization to nucleus|
|positive regulation of chromosome organization|
|regulation of phosphatase activity|
|positive regulation of DNA metabolic process|
|regulation of dephosphorylation|
|regulation of response to DNA damage stimulus|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear body|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of cell cycle|
|establishment of protein localization to organelle|
|negative regulation of hydrolase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|intracellular protein transport|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|RNA binding|
|DNA binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.71|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.72|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.81|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.87|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.88|
|[[:results:exp453|B02 10μM R08 exp453]]|1.89|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.03|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.06|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.24|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc84|CCDC84]]|0.456|
|[[:human genes:s:slc6a17|SLC6A17]]|0.418|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.414|
|[[:human genes:c:chd4|CHD4]]|0.41|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 558/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|21/28|
|blood|19/28|
|bone|21/26|
|breast|18/33|
|central nervous system|39/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|14/21|
|liver|17/20|
|lung|57/75|
|lymphocyte|15/16|
|ovary|18/26|
|pancreas|19/24|
|peripheral nervous system|13/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|15/22|
|urinary tract|21/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 413
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R10 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>