======= PPP1R12A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R12A
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 12A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4659|4659]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14974|O14974]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R12A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R12A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602021|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of myosin-light-chain-phosphatase activity|
|contractile fiber|
|PTW/PP1 phosphatase complex|
|regulation of myosin-light-chain-phosphatase activity|
|phosphatase regulator activity|
|A band|
|regulation of endothelial cell development|
|regulation of establishment of endothelial barrier|
|positive regulation of phosphoprotein phosphatase activity|
|14-3-3 protein binding|
|enzyme inhibitor activity|
|regulation of endothelial cell differentiation|
|positive regulation of phosphatase activity|
|positive regulation of protein dephosphorylation|
|positive regulation of dephosphorylation|
|centrosome cycle|
|kinetochore|
|microtubule organizing center organization|
|regulation of nucleocytoplasmic transport|
|regulation of phosphoprotein phosphatase activity|
|G2/M transition of mitotic cell cycle|
|Z disc|
|cell cycle G2/M phase transition|
|regulation of protein dephosphorylation|
|regulation of epithelial cell differentiation|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|protein dephosphorylation|
|actin cytoskeleton|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|dephosphorylation|
|regulation of intracellular transport|
|cellular response to drug|
|focal adhesion|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|mitotic cell cycle process|
|microtubule-based process|
|regulation of cell adhesion|
|mitotic cell cycle|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of cellular localization|
|regulation of cell development|
|cell cycle process|
|response to drug|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|cell cycle|
|positive regulation of catalytic activity|
|positive regulation of transcription, DNA-templated|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.65|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.55|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.25|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.24|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.02|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.01|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.99|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.92|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.9|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.82|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.8|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.77|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.73|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.72|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.71|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.7|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.73|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.76|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.9|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 539/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|14/28|
|bone|18/26|
|breast|22/33|
|central nervous system|45/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|15/21|
|liver|11/20|
|lung|50/75|
|lymphocyte|9/16|
|ovary|21/26|
|pancreas|17/24|
|peripheral nervous system|6/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1553
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R12A Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>