======= PPP1R3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R3B
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 3B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79660|79660]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86XI6|Q86XI6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610541|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBM 21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|[phosphorylase] phosphatase activity|
|regulation of glycogen catabolic process|
|glycogen granule|
|protein phosphatase type 1 complex|
|regulation of cellular carbohydrate catabolic process|
|regulation of glycogen biosynthetic process|
|regulation of glucan biosynthetic process|
|protein phosphatase regulator activity|
|regulation of glycogen metabolic process|
|regulation of polysaccharide biosynthetic process|
|regulation of polysaccharide metabolic process|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|energy reserve metabolic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|regulation of carbohydrate catabolic process|
|regulation of carbohydrate biosynthetic process|
|regulation of glucose metabolic process|
|regulation of phosphoprotein phosphatase activity|
|regulation of cellular carbohydrate metabolic process|
|regulation of protein dephosphorylation|
|regulation of generation of precursor metabolites and energy|
|cellular carbohydrate metabolic process|
|regulation of phosphatase activity|
|regulation of carbohydrate metabolic process|
|regulation of dephosphorylation|
|protein dephosphorylation|
|energy derivation by oxidation of organic compounds|
|dephosphorylation|
|enzyme binding|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|carbohydrate metabolic process|
|intracellular membrane-bounded organelle|
|regulation of cellular catabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
|regulation of hydrolase activity|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R3B Expression in NALM6 Cells: 3.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>