======= PPP1R3D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R3D
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 3D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5509|5509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95685|O95685]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R3D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R3D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603326|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBM 21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of glycogen catabolic process|
|glycogen granule|
|regulation of cellular carbohydrate catabolic process|
|regulation of glucan biosynthetic process|
|regulation of glycogen biosynthetic process|
|regulation of glycogen metabolic process|
|regulation of polysaccharide biosynthetic process|
|regulation of polysaccharide metabolic process|
|glycogen metabolic process|
|glucan metabolic process|
|cellular glucan metabolic process|
|energy reserve metabolic process|
|protein serine/threonine phosphatase activity|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|regulation of carbohydrate catabolic process|
|regulation of carbohydrate biosynthetic process|
|regulation of glucose metabolic process|
|regulation of cellular carbohydrate metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular carbohydrate metabolic process|
|regulation of carbohydrate metabolic process|
|protein dephosphorylation|
|energy derivation by oxidation of organic compounds|
|dephosphorylation|
|enzyme binding|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|carbohydrate metabolic process|
|intracellular membrane-bounded organelle|
|regulation of cellular catabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R3D Expression in NALM6 Cells: 2.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>