======= PPP5C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP5C
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 5 catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5536|5536]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53041|P53041]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP5C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP5C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600658|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. {ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15383005, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:19948726, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:9000529}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 2|
|PPP5|
|TPR 1|
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to arachidonic acid|
|positive regulation of glucocorticoid receptor signaling pathway|
|proximal dendrite|
|histone dephosphorylation|
|regulation of glucocorticoid receptor signaling pathway|
|chaperone complex|
|positive regulation of intracellular steroid hormone receptor signaling pathway|
|peptidyl-serine dephosphorylation|
|peptidyl-threonine dephosphorylation|
|response to lead ion|
|G-protein alpha-subunit binding|
|response to isoquinoline alkaloid|
|response to morphine|
|ADP binding|
|cellular response to cadmium ion|
|Hsp90 protein binding|
|phosphoprotein phosphatase activity|
|tau protein binding|
|phosphatase activity|
|protein serine/threonine phosphatase activity|
|response to cadmium ion|
|cellular response to hydrogen peroxide|
|regulation of intracellular steroid hormone receptor signaling pathway|
|response to anesthetic|
|response to fatty acid|
|protein heterooligomerization|
|response to alkaloid|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|cellular response to reactive oxygen species|
|perikaryon|
|lipid binding|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|response to ammonium ion|
|cellular response to metal ion|
|response to reactive oxygen species|
|negative regulation of neuron death|
|cellular response to toxic substance|
|protein dephosphorylation|
|cellular response to inorganic substance|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|microtubule binding|
|cellular response to oxidative stress|
|response to xenobiotic stimulus|
|response to antibiotic|
|dephosphorylation|
|regulation of neuron death|
|response to acid chemical|
|histone modification|
|response to metal ion|
|MAPK cascade|
|covalent chromatin modification|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|response to toxic substance|
|DNA repair|
|protein complex oligomerization|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|response to lipid|
|response to organic cyclic compound|
|protein phosphorylation|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|identical protein binding|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|cell cycle|
|RNA binding|
|regulation of protein phosphorylation|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.73|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.74|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.79|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.8|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.8|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.81|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.81|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.83|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.84|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.93|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.97|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.09|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.12|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.2|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.21|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.26|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.34|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.44|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.45|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.51|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.83|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:triap1|TRIAP1]]|0.477|
|[[:human genes:p:plaa|PLAA]]|0.463|
|[[:human genes:a:apaf1|APAF1]]|0.415|
|[[:human genes:p:pmm2|PMM2]]|0.414|
|[[:human genes:d:dohh|DOHH]]|0.413|
|[[:human genes:b:bap1|BAP1]]|0.409|
|[[:human genes:h:hccs|HCCS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9029
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP5C Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>