======= PPP6C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP6C
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 6 catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5537|5537]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00743|O00743]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP6C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP6C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612725|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation. {ECO:0000269|PubMed:10227379, ECO:0000269|PubMed:17079228, ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:29053956, ECO:0000269|PubMed:9013334}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|protein serine/threonine phosphatase activity|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|protein dephosphorylation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|vesicle organization|
|dephosphorylation|
|establishment of organelle localization|
|Golgi vesicle transport|
|organelle localization|
|mitotic cell cycle process|
|Golgi membrane|
|mitotic cell cycle|
|innate immune response|
|membrane organization|
|defense response to other organism|
|cell cycle process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|defense response|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-3.52|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.37|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.34|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.27|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.14|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.08|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.04|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.94|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.93|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.91|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.83|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.81|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.79|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.76|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.75|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.71|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.7|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.78|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.83|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.83|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.85|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.87|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.89|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.93|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.94|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.05|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.08|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.09|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.11|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.15|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.22|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.27|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.27|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.28|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.36|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.37|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.39|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.39|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.43|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.45|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.67|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.69|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.8|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.92|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.13|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|3.13|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.22|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|3.33|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|3.97|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.97|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|4.1|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.21|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|4.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fh|FH]]|0.574|
|[[:human genes:t:thg1l|THG1L]]|0.56|
|[[:human genes:p:ptar1|PTAR1]]|0.548|
|[[:human genes:d:dr1|DR1]]|0.531|
|[[:human genes:g:gemin8|GEMIN8]]|0.528|
|[[:human genes:p:ppp2r4|PPP2R4]]|0.523|
|[[:human genes:b:bap1|BAP1]]|0.52|
|[[:human genes:k:kctd5|KCTD5]]|0.519|
|[[:human genes:r:rabggtb|RABGGTB]]|0.517|
|[[:human genes:g:gemin6|GEMIN6]]|0.517|
|[[:human genes:a:alg1|ALG1]]|0.516|
|[[:human genes:m:mbtps2|MBTPS2]]|0.509|
|[[:human genes:a:atxn10|ATXN10]]|0.507|
|[[:human genes:r:rpp21|RPP21]]|0.507|
|[[:human genes:l:lsm10|LSM10]]|0.504|
|[[:human genes:u:uap1|UAP1]]|0.501|
|[[:human genes:d:ddx42|DDX42]]|0.5|
|[[:human genes:g:gemin7|GEMIN7]]|0.499|
|[[:human genes:d:dohh|DOHH]]|0.497|
|[[:human genes:c:cbx3|CBX3]]|0.493|
|[[:human genes:a:adsl|ADSL]]|0.491|
|[[:human genes:u:uhrf1|UHRF1]]|0.49|
|[[:human genes:s:srp14|SRP14]]|0.488|
|[[:human genes:p:ppcs|PPCS]]|0.488|
|[[:human genes:p:pdap1|PDAP1]]|0.487|
|[[:human genes:z:zcrb1|ZCRB1]]|0.485|
|[[:human genes:p:ppp4c|PPP4C]]|0.482|
|[[:human genes:t:tmem242|TMEM242]]|0.482|
|[[:human genes:r:rft1|RFT1]]|0.481|
|[[:human genes:d:dpagt1|DPAGT1]]|0.473|
|[[:human genes:c:c15orf41|C15orf41]]|0.468|
|[[:human genes:v:vezt|VEZT]]|0.468|
|[[:human genes:r:rptor|RPTOR]]|0.467|
|[[:human genes:n:nae1|NAE1]]|0.465|
|[[:human genes:c:cyb5r4|CYB5R4]]|0.464|
|[[:human genes:w:wrb|WRB]]|0.464|
|[[:human genes:r:rtcb|RTCB]]|0.462|
|[[:human genes:z:zrsr2|ZRSR2]]|0.462|
|[[:human genes:p:ppcdc|PPCDC]]|0.459|
|[[:human genes:l:lcmt1|LCMT1]]|0.459|
|[[:human genes:p:pmm2|PMM2]]|0.458|
|[[:human genes:e:exoc4|EXOC4]]|0.457|
|[[:human genes:a:atp5b|ATP5B]]|0.457|
|[[:human genes:s:slc25a19|SLC25A19]]|0.457|
|[[:human genes:p:pgm3|PGM3]]|0.457|
|[[:human genes:l:lsm11|LSM11]]|0.453|
|[[:human genes:t:trmt5|TRMT5]]|0.451|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.45|
|[[:human genes:g:gmppb|GMPPB]]|0.45|
|[[:human genes:d:dhrsx|DHRSX]]|0.449|
|[[:human genes:r:rpia|RPIA]]|0.448|
|[[:human genes:u:uba3|UBA3]]|0.448|
|[[:human genes:c:cxorf56|CXorf56]]|0.448|
|[[:human genes:m:msto1|MSTO1]]|0.445|
|[[:human genes:t:ttc4|TTC4]]|0.444|
|[[:human genes:t:ten1|TEN1]]|0.442|
|[[:human genes:u:urm1|URM1]]|0.441|
|[[:human genes:t:tpk1|TPK1]]|0.44|
|[[:human genes:b:bak1|BAK1]]|0.435|
|[[:human genes:u:ube2m|UBE2M]]|0.434|
|[[:human genes:t:tbcb|TBCB]]|0.434|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.434|
|[[:human genes:g:gemin4|GEMIN4]]|0.433|
|[[:human genes:a:atp5o|ATP5O]]|0.433|
|[[:human genes:d:ddx1|DDX1]]|0.433|
|[[:human genes:d:dph1|DPH1]]|0.432|
|[[:human genes:a:ankrd52|ANKRD52]]|0.431|
|[[:human genes:s:ssb|SSB]]|0.43|
|[[:human genes:e:elp3|ELP3]]|0.43|
|[[:human genes:t:tsen54|TSEN54]]|0.427|
|[[:human genes:a:alg6|ALG6]]|0.425|
|[[:human genes:f:fen1|FEN1]]|0.424|
|[[:human genes:t:trmt61a|TRMT61A]]|0.423|
|[[:human genes:e:elp2|ELP2]]|0.422|
|[[:human genes:a:atp5j|ATP5J]]|0.419|
|[[:human genes:g:gfpt1|GFPT1]]|0.418|
|[[:human genes:n:n6amt1|N6AMT1]]|0.418|
|[[:human genes:c:cep57|CEP57]]|0.418|
|[[:human genes:a:atp5a1|ATP5A1]]|0.416|
|[[:human genes:f:faf2|FAF2]]|0.415|
|[[:human genes:t:trim28|TRIM28]]|0.415|
|[[:human genes:s:snapc5|SNAPC5]]|0.415|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.415|
|[[:human genes:b:brwd1|BRWD1]]|0.414|
|[[:human genes:d:ddx39a|DDX39A]]|0.414|
|[[:human genes:t:tube1|TUBE1]]|0.413|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.412|
|[[:human genes:p:pdcd6ip|PDCD6IP]]|0.412|
|[[:human genes:t:timm10|TIMM10]]|0.412|
|[[:human genes:s:spr|SPR]]|0.412|
|[[:human genes:p:pdcd5|PDCD5]]|0.411|
|[[:human genes:t:tubd1|TUBD1]]|0.411|
|[[:human genes:a:atic|ATIC]]|0.411|
|[[:human genes:s:srrd|SRRD]]|0.411|
|[[:human genes:p:pelo|PELO]]|0.409|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.407|
|[[:human genes:e:egln1|EGLN1]]|0.406|
|[[:human genes:k:kdm8|KDM8]]|0.405|
|[[:human genes:b:bcs1l|BCS1L]]|0.404|
|[[:human genes:s:slc25a26|SLC25A26]]|0.403|
|[[:human genes:t:tut1|TUT1]]|0.402|
|[[:human genes:t:taf1a|TAF1A]]|0.401|
|[[:human genes:h:hars|HARS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 396/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|14/28|
|bone|11/26|
|breast|24/33|
|central nervous system|20/56|
|cervix|2/4|
|colorectal|11/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|10/21|
|liver|12/20|
|lung|38/75|
|lymphocyte|11/16|
|ovary|14/26|
|pancreas|14/24|
|peripheral nervous system|3/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|3/9|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|21/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP6C Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>