======= PQLC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC66A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 66 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54896|54896]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZP29|Q6ZP29]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PQLC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PQLC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO:0000269|PubMed:22822152, ECO:0000269|PubMed:23169667}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PQ-loop|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysine transport|
|arginine transmembrane transporter activity|
|L-lysine transmembrane transporter activity|
|amino acid homeostasis|
|L-lysine transmembrane transport|
|L-lysine transport|
|arginine transmembrane transport|
|basic amino acid transmembrane transporter activity|
|arginine transport|
|basic amino acid transmembrane transport|
|integral component of organelle membrane|
|basic amino acid transport|
|L-alpha-amino acid transmembrane transport|
|anion homeostasis|
|L-amino acid transport|
|drug transmembrane transport|
|amino acid transmembrane transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|drug transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|lysosomal membrane|
|organic anion transport|
|anion transport|
|cation transmembrane transport|
|intracellular membrane-bounded organelle|
|ion homeostasis|
|cation transport|
|ion transmembrane transport|
|response to drug|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.76|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.7|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PQLC2 Expression in NALM6 Cells: 2.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>