======= PRDM12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDM12
  * **<color #00a2e8>Official Name</color>**: PR/SET domain 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59335|59335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4Q4|Q9H4Q4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDM12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDM12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616458|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the positive regulation of histone H3-K9 dimethylation. {ECO:0000269|PubMed:26005867}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of histone H3-K9 dimethylation|
|regulation of histone H3-K9 dimethylation|
|histone methyltransferase binding|
|positive regulation of histone H3-K9 methylation|
|detection of temperature stimulus involved in sensory perception of pain|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus|
|sensory perception of temperature stimulus|
|regulation of histone H3-K9 methylation|
|positive regulation of histone methylation|
|methyltransferase activity|
|regulation of histone methylation|
|chromatin DNA binding|
|sensory perception of pain|
|positive regulation of histone modification|
|positive regulation of chromatin organization|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of histone modification|
|positive regulation of chromosome organization|
|response to temperature stimulus|
|regulation of chromatin organization|
|methylation|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of chromosome organization|
|sequence-specific DNA binding|
|detection of stimulus involved in sensory perception|
|positive regulation of organelle organization|
|neuron projection development|
|DNA-binding transcription factor activity|
|detection of stimulus|
|neuron development|
|sensory perception|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|nervous system process|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.95|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15247
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDM12 Expression in NALM6 Cells: -0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>