======= PRDM14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDM14
  * **<color #00a2e8>Official Name</color>**: PR/SET domain 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63978|63978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZV8|Q9GZV8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDM14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDM14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611781|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. {ECO:0000250|UniProtKB:E9Q3T6, ECO:0000269|PubMed:17942894, ECO:0000269|PubMed:20953172}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inactivation of paternal X chromosome|
|histone H3-R26 methylation|
|inner cell mass cell fate commitment|
|germ-line stem cell population maintenance|
|inner cell mass cell differentiation|
|positive regulation of stem cell population maintenance|
|positive regulation of cilium-dependent cell motility|
|positive regulation of flagellated sperm motility|
|histone arginine methylation|
|peptidyl-arginine methylation|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|regulation of flagellated sperm motility|
|dosage compensation by inactivation of X chromosome|
|dosage compensation|
|regulation of cilium-dependent cell motility|
|regulation of DNA methylation|
|peptidyl-arginine modification|
|regulation of stem cell population maintenance|
|regulation of fibroblast growth factor receptor signaling pathway|
|homeostasis of number of cells within a tissue|
|embryo implantation|
|blastocyst formation|
|methyltransferase activity|
|somatic stem cell population maintenance|
|chromatin DNA binding|
|positive regulation of reproductive process|
|cell fate specification|
|histone methylation|
|blastocyst development|
|protein methylation|
|protein alkylation|
|stem cell population maintenance|
|maintenance of cell number|
|negative regulation of cellular response to growth factor stimulus|
|regulation of reproductive process|
|fertilization|
|female pregnancy|
|tissue homeostasis|
|homeostasis of number of cells|
|multi-multicellular organism process|
|regulation of gene expression, epigenetic|
|cell fate commitment|
|macromolecule methylation|
|germ cell development|
|regulation of cellular response to growth factor stimulus|
|methylation|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|in utero embryonic development|
|sequence-specific DNA binding|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|gamete generation|
|chromatin organization|
|cell morphogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|embryo development|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14320
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDM14 Expression in NALM6 Cells: 0.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>