======= PRDM9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDM9
  * **<color #00a2e8>Official Name</color>**: PR/SET domain 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56979|56979]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQV7|Q9NQV7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDM9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDM9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KRAB|
|SSXRD|
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|recombination hotspot binding|
|meiotic gene conversion|
|regulation of reciprocal meiotic recombination|
|positive regulation of reciprocal meiotic recombination|
|gene conversion|
|positive regulation of meiosis I|
|regulation of meiosis I|
|positive regulation of meiotic nuclear division|
|histone methyltransferase activity (H3-K4 specific)|
|nucleosome positioning|
|histone-lysine N-methyltransferase activity|
|positive regulation of meiotic cell cycle|
|regulation of meiotic nuclear division|
|histone H3-K4 methylation|
|positive regulation of DNA recombination|
|regulation of meiotic cell cycle|
|positive regulation of nuclear division|
|chromatin DNA binding|
|histone lysine methylation|
|positive regulation of reproductive process|
|peptidyl-lysine methylation|
|histone methylation|
|regulation of DNA recombination|
|meiosis I cell cycle process|
|chromosome|
|chromatin assembly|
|protein methylation|
|protein alkylation|
|chromatin assembly or disassembly|
|nucleosome organization|
|regulation of reproductive process|
|meiotic cell cycle process|
|DNA packaging|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|transcription regulatory region DNA binding|
|DNA recombination|
|meiotic cell cycle|
|protein-DNA complex subunit organization|
|macromolecule methylation|
|positive regulation of cell cycle process|
|DNA conformation change|
|methylation|
|peptidyl-lysine modification|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|positive regulation of cell cycle|
|sequence-specific DNA binding|
|positive regulation of organelle organization|
|DNA-binding transcription factor activity|
|chromatin organization|
|DNA metabolic process|
|regulation of cell cycle process|
|peptidyl-amino acid modification|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.82|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16458
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDM9 Expression in NALM6 Cells: -1.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>