======= PRDX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDX3
  * **<color #00a2e8>Official Name</color>**: peroxiredoxin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10935|10935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30048|P30048]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604769|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AhpC-TSA|
|Redoxin|
|1-cysPrx C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alkyl hydroperoxide reductase activity|
|peptidyl-cysteine oxidation|
|thioredoxin peroxidase activity|
|protein oxidation|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|hydrogen peroxide catabolic process|
|maternal placenta development|
|hydrogen peroxide metabolic process|
|peptidyl-cysteine modification|
|antibiotic catabolic process|
|cofactor catabolic process|
|maternal process involved in female pregnancy|
|regulation of mitochondrial membrane potential|
|cell redox homeostasis|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|cellular oxidant detoxification|
|kinase binding|
|cellular detoxification|
|antibiotic metabolic process|
|reactive oxygen species metabolic process|
|response to hydrogen peroxide|
|detoxification|
|cellular response to reactive oxygen species|
|drug catabolic process|
|placenta development|
|positive regulation of NF-kappaB transcription factor activity|
|female pregnancy|
|protein C-terminus binding|
|response to reactive oxygen species|
|multi-multicellular organism process|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|myeloid cell differentiation|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of kinase activity|
|negative regulation of peptidase activity|
|early endosome|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of transferase activity|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|negative regulation of proteolysis|
|mitochondrial matrix|
|response to oxidative stress|
|regulation of endopeptidase activity|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|regulation of membrane potential|
|cofactor metabolic process|
|mitochondrion organization|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|protein kinase binding|
|drug metabolic process|
|response to toxic substance|
|response to inorganic substance|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|immune system development|
|developmental process involved in reproduction|
|response to bacterium|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|oxidation-reduction process|
|regulation of transferase activity|
|multi-organism reproductive process|
|negative regulation of cell death|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|mitochondrion|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15518
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDX3 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>