======= PRDX6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDX6
  * **<color #00a2e8>Official Name</color>**: peroxiredoxin 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9588|9588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30041|P30041]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDX6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDX6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602316|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. {ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:9497358}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|1-cysPrx C|
|Redoxin|
|AhpC-TSA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peroxiredoxin activity|
|calcium-independent phospholipase A2 activity|
|positive regulation of mRNA splicing, via spliceosome|
|glutathione peroxidase activity|
|glycerophospholipid catabolic process|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|hydrogen peroxide catabolic process|
|positive regulation of mRNA processing|
|peroxidase activity|
|positive regulation of RNA splicing|
|phospholipid catabolic process|
|hydrogen peroxide metabolic process|
|antibiotic catabolic process|
|glycerolipid catabolic process|
|cofactor catabolic process|
|cell redox homeostasis|
|positive regulation of mRNA metabolic process|
|azurophil granule lumen|
|cellular oxidant detoxification|
|regulation of mRNA splicing, via spliceosome|
|cellular detoxification|
|antibiotic metabolic process|
|reactive oxygen species metabolic process|
|detoxification|
|organophosphate catabolic process|
|regulation of RNA splicing|
|regulation of mRNA processing|
|drug catabolic process|
|cellular lipid catabolic process|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|ubiquitin protein ligase binding|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|cadherin binding|
|regulation of mRNA metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to oxidative stress|
|cofactor metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|protein homodimerization activity|
|organophosphate metabolic process|
|cellular homeostasis|
|leukocyte activation|
|cellular lipid metabolic process|
|oxidation-reduction process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|lipid metabolic process|
|extracellular space|
|homeostatic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-3.18|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.85|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.71|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.554|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18430
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDX6 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>