======= PRKCB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKCB
  * **<color #00a2e8>Official Name</color>**: protein kinase C beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5579|5579]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05771|P05771]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKCB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKCB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase C|
|C1 1|
|Pkinase|
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-T6 phosphorylation|
|histone kinase activity (H3-T6 specific)|
|histone-threonine phosphorylation|
|positive regulation of B cell receptor signaling pathway|
|lipoprotein transport|
|mitotic nuclear envelope disassembly|
|lipoprotein localization|
|presynaptic modulation of chemical synaptic transmission|
|presynaptic cytosol|
|protein kinase C activity|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|nuclear envelope disassembly|
|membrane disassembly|
|negative regulation of glucose transmembrane transport|
|positive regulation of antigen receptor-mediated signaling pathway|
|calyx of Held|
|regulation of B cell receptor signaling pathway|
|histone phosphorylation|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|calcium channel regulator activity|
|androgen receptor binding|
|nuclear envelope organization|
|protein kinase C binding|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of insulin receptor signaling pathway|
|nuclear receptor transcription coactivator activity|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|regulation of synaptic vesicle exocytosis|
|cellular response to carbohydrate stimulus|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|negative regulation of transmembrane transport|
|B cell receptor signaling pathway|
|histone binding|
|nucleus organization|
|platelet activation|
|regulation of neurotransmitter transport|
|positive regulation of NF-kappaB transcription factor activity|
|B cell activation|
|regulation of regulated secretory pathway|
|positive regulation of angiogenesis|
|response to carbohydrate|
|peptidyl-serine phosphorylation|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|peptidyl-serine modification|
|regulation of exocytosis|
|regulation of myeloid cell differentiation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|calcium ion transport|
|positive regulation of DNA-binding transcription factor activity|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|blood coagulation|
|antigen receptor-mediated signaling pathway|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|divalent inorganic cation transport|
|regulation of vasculature development|
|regulation of neurotransmitter levels|
|protein serine/threonine kinase activity|
|histone modification|
|covalent chromatin modification|
|lymphocyte activation|
|chromatin binding|
|cellular component disassembly|
|endomembrane system organization|
|regulation of DNA-binding transcription factor activity|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|regulation of hemopoiesis|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|response to wounding|
|immune response-regulating signaling pathway|
|mitotic cell cycle process|
|adaptive immune response|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|mitotic cell cycle|
|chromatin organization|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|zinc ion binding|
|membrane organization|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|cellular homeostasis|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|protein phosphorylation|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell activation|
|cell death|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|ATP binding|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.05|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.75|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.75|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.77|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.79|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3655
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKCB Expression in NALM6 Cells: 0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>