======= PRKDC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKDC
  * **<color #00a2e8>Official Name</color>**: protein kinase, DNA-activated, catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5591|5591]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78527|P78527]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKDC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKDC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600899|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of response to gamma radiation|
|regulation of response to gamma radiation|
|double-strand break repair via alternative nonhomologous end joining|
|DNA-dependent protein kinase activity|
|DNA-dependent protein kinase-DNA ligase 4 complex|
|pro-B cell differentiation|
|somatic diversification of T cell receptor genes|
|immunoglobulin V(D)J recombination|
|T cell receptor V(D)J recombination|
|somatic recombination of T cell receptor gene segments|
|B cell lineage commitment|
|ectopic germ cell programmed cell death|
|nonhomologous end joining complex|
|programmed cell death involved in cell development|
|negative regulation of immunoglobulin production|
|lymphoid progenitor cell differentiation|
|positive regulation of double-strand break repair via nonhomologous end joining|
|V(D)J recombination|
|negative regulation of cellular senescence|
|telomere capping|
|T cell lineage commitment|
|regulation of double-strand break repair via nonhomologous end joining|
|negative regulation of cell aging|
|somatic recombination of immunoglobulin gene segments|
|positive regulation of double-strand break repair|
|spleen development|
|negative regulation of production of molecular mediator of immune response|
|somatic cell DNA recombination|
|somatic diversification of immunoglobulins|
|somatic diversification of immune receptors via germline recombination within a single locus|
|regulation of cellular senescence|
|protein-DNA complex|
|thymus development|
|protein destabilization|
|T cell differentiation in thymus|
|regulation of cell aging|
|somatic diversification of immune receptors|
|positive regulation of fibroblast proliferation|
|response to gamma radiation|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|double-strand break repair via nonhomologous end joining|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|non-recombinational repair|
|G1 DNA damage checkpoint|
|regulation of immunoglobulin production|
|response to activity|
|somitogenesis|
|positive regulation of DNA repair|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of type I interferon production|
|regulation of double-strand break repair|
|regulation of fibroblast proliferation|
|somite development|
|hematopoietic progenitor cell differentiation|
|mitotic DNA damage checkpoint|
|segmentation|
|telomere maintenance|
|positive regulation of response to DNA damage stimulus|
|telomere organization|
|negative regulation of G1/S transition of mitotic cell cycle|
|double-stranded DNA binding|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|B cell differentiation|
|nuclear chromosome, telomeric region|
|regulation of circadian rhythm|
|negative regulation of immune effector process|
|regulation of DNA repair|
|regulation of type I interferon production|
|DNA damage checkpoint|
|regulation of smooth muscle cell proliferation|
|T cell differentiation|
|regulation of production of molecular mediator of immune response|
|DNA integrity checkpoint|
|intrinsic apoptotic signaling pathway|
|response to ionizing radiation|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|B cell activation|
|immunoglobulin production|
|cellular response to insulin stimulus|
|regulation of cell cycle G1/S phase transition|
|positive regulation of developmental growth|
|peptidyl-serine phosphorylation|
|production of molecular mediator of immune response|
|double-strand break repair|
|cell cycle checkpoint|
|positive regulation of DNA metabolic process|
|peptidyl-serine modification|
|transcription factor complex|
|negative regulation of mitotic cell cycle phase transition|
|anterior/posterior pattern specification|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|response to insulin|
|negative regulation of cell cycle phase transition|
|T cell activation|
|lymphocyte differentiation|
|protein kinase activity|
|protein domain specific binding|
|cell fate commitment|
|activation of innate immune response|
|positive regulation of growth|
|cellular response to peptide hormone stimulus|
|rhythmic process|
|apoptotic signaling pathway|
|regulation of protein stability|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|cellular response to peptide|
|regulation of developmental growth|
|leukocyte differentiation|
|regionalization|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|positive regulation of innate immune response|
|anatomical structure homeostasis|
|enzyme binding|
|regulation of DNA metabolic process|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|lymphocyte activation|
|response to peptide hormone|
|negative regulation of protein phosphorylation|
|gland development|
|regulation of mitotic cell cycle phase transition|
|pattern specification process|
|response to radiation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|response to peptide|
|positive regulation of defense response|
|DNA repair|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|heart development|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|protein-containing complex|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|regulation of growth|
|mitotic cell cycle|
|protein ubiquitination|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of cellular response to stress|
|brain development|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of defense response|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|head development|
|nucleolus|
|positive regulation of immune response|
|circulatory system development|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|chromosome organization|
|cell activation|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|epithelium development|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|defense response|
|positive regulation of developmental process|
|RNA binding|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.22|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.19|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.16|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.01|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.01|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.93|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.9|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.81|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.75|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.491|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1637
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKDC Expression in NALM6 Cells: 10.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>