======= PRMT10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRMT9
  * **<color #00a2e8>Official Name</color>**: protein arginine methyltransferase 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90826|90826]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P2P2|Q6P2P2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRMT10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRMT10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344). {ECO:0000269|PubMed:25737013, ECO:0000269|PubMed:25979344}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PrmA|
|Methyltransf 18|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|
|protein-arginine omega-N symmetric methyltransferase activity|
|protein-arginine omega-N monomethyltransferase activity|
|protein-arginine N-methyltransferase activity|
|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|
|protein-arginine omega-N asymmetric methyltransferase activity|
|histone-arginine N-methyltransferase activity|
|peptidyl-arginine omega-N-methylation|
|peptidyl-arginine N-methylation|
|histone arginine methylation|
|peptidyl-arginine methylation|
|peptidyl-arginine modification|
|histone methylation|
|protein methylation|
|protein alkylation|
|macromolecule methylation|
|methylation|
|histone modification|
|covalent chromatin modification|
|mRNA processing|
|mRNA metabolic process|
|chromatin organization|
|RNA processing|
|peptidyl-amino acid modification|
|chromosome organization|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.98|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.06|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.09|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.11|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.17|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mbnl1|MBNL1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRMT10 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>