======= PRMT5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRMT5
  * **<color #00a2e8>Official Name</color>**: protein arginine methyltransferase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10419|10419]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14744|O14744]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRMT5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRMT5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRMT5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|
|regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|
|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|
|protein-arginine omega-N symmetric methyltransferase activity|
|histone methyltransferase activity (H4-R3 specific)|
|positive regulation of dopamine receptor signaling pathway|
|histone H4-R3 methylation|
|protein-arginine N-methyltransferase activity|
|histone-arginine N-methyltransferase activity|
|peptidyl-arginine omega-N-methylation|
|endothelial cell activation|
|positive regulation of cellular response to drug|
|peptidyl-arginine N-methylation|
|regulation of dopamine receptor signaling pathway|
|Golgi ribbon formation|
|methylosome|
|histone arginine methylation|
|peptidyl-arginine methylation|
|positive regulation of oligodendrocyte differentiation|
|regulation of DNA methylation|
|methyl-CpG binding|
|peptidyl-arginine modification|
|positive regulation of G protein-coupled receptor signaling pathway|
|liver regeneration|
|positive regulation of response to drug|
|ribonucleoprotein complex binding|
|regulation of cellular response to drug|
|spliceosomal snRNP assembly|
|regulation of oligodendrocyte differentiation|
|histone methyltransferase complex|
|positive regulation of glial cell differentiation|
|E-box binding|
|methyltransferase activity|
|circadian regulation of gene expression|
|p53 binding|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|DNA-templated transcription, termination|
|animal organ regeneration|
|histone methylation|
|regulation of response to drug|
|regulation of gliogenesis|
|liver development|
|hepaticobiliary system development|
|Golgi organization|
|protein methylation|
|protein alkylation|
|circadian rhythm|
|regulation of G protein-coupled receptor signaling pathway|
|regeneration|
|regulation of mitotic nuclear division|
|regulation of signal transduction by p53 class mediator|
|regulation of nuclear division|
|ribonucleoprotein complex assembly|
|transcription corepressor activity|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|rhythmic process|
|regulation of ERK1 and ERK2 cascade|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|methylation|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|RNA splicing|
|gland development|
|endomembrane system organization|
|ribonucleoprotein complex biogenesis|
|positive regulation of neurogenesis|
|mRNA processing|
|protein heterodimerization activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|RNA processing|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|Golgi apparatus|
|chromosome organization|
|identical protein binding|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of phosphorylation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.68|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.59|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.57|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.01|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.98|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.89|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.78|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.77|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.76|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.76|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.75|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.73|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.72|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.76|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.77|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.83|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.87|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.9|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.01|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.24|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.436|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 638/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|26/28|
|bone|21/25|
|breast|27/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|20/21|
|liver|18/20|
|lung|67/75|
|lymphocyte|12/14|
|ovary|20/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 24
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRMT5 Expression in NALM6 Cells: 7.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>