======= PROC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PROC
  * **<color #00a2e8>Official Name</color>**: protein C, inactivator of coagulation factors Va and VIIIa
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5624|5624]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04070|P04070]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PROC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PROC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612283|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). {ECO:0000269|PubMed:25618265, ECO:0000269|PubMed:25651845}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
|Gla|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of establishment of endothelial barrier|
|positive regulation of endothelial cell development|
|regulation of endothelial cell development|
|regulation of establishment of endothelial barrier|
|positive regulation of endothelial cell differentiation|
|regulation of endothelial cell differentiation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of epithelial cell differentiation|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|Golgi lumen|
|negative regulation of inflammatory response|
|regulation of wound healing|
|regulation of epithelial cell differentiation|
|serine-type endopeptidase activity|
|regulation of response to wounding|
|negative regulation of defense response|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|blood coagulation|
|coagulation|
|hemostasis|
|endoplasmic reticulum lumen|
|regulation of inflammatory response|
|post-translational protein modification|
|negative regulation of response to external stimulus|
|Golgi vesicle transport|
|wound healing|
|regulation of body fluid levels|
|positive regulation of cell development|
|response to wounding|
|calcium ion binding|
|regulation of defense response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell development|
|positive regulation of cell differentiation|
|Golgi apparatus|
|negative regulation of cell death|
|endoplasmic reticulum|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|positive regulation of developmental process|
|regulation of response to stress|
|intracellular transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of cell differentiation|
|establishment of localization in cell|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.81|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.79|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11319
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PROC Expression in NALM6 Cells: -1.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>