======= PRODH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRODH
  * **<color #00a2e8>Official Name</color>**: proline dehydrogenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5625|5625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43272|O43272]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRODH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRODH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Converts proline to delta-1-pyrroline-5-carboxylate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proline dehydrogenase activity|
|proline catabolic process to glutamate|
|proline catabolic process|
|4-hydroxyproline catabolic process|
|proline metabolic process|
|4-hydroxyproline metabolic process|
|intrinsic apoptotic signaling pathway in response to oxidative stress|
|cell death in response to oxidative stress|
|glutamine family amino acid catabolic process|
|cellular modified amino acid catabolic process|
|glutamate metabolic process|
|FAD binding|
|glutamine family amino acid metabolic process|
|dicarboxylic acid metabolic process|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|intrinsic apoptotic signaling pathway|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|cellular response to oxidative stress|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|apoptotic signaling pathway|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|response to oxidative stress|
|mitochondrial inner membrane|
|heterocycle catabolic process|
|small molecule catabolic process|
|organic cyclic compound catabolic process|
|positive regulation of cell death|
|carboxylic acid metabolic process|
|apoptotic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|mitochondrion|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.79|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.83|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3896
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRODH Expression in NALM6 Cells: 1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>