======= PROM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PROM1
  * **<color #00a2e8>Official Name</color>**: prominin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8842|8842]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43490|O43490]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PROM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PROM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604365|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). {ECO:0000269|PubMed:20818439, ECO:0000269|PubMed:24556617}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prominin|
|Tweety|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prominosome|
|positive regulation of nephron tubule epithelial cell differentiation|
|glomerular parietal epithelial cell differentiation|
|positive regulation of epithelial cell differentiation involved in kidney development|
|actinin binding|
|regulation of nephron tubule epithelial cell differentiation|
|glomerular visceral epithelial cell differentiation|
|renal filtration cell differentiation|
|photoreceptor outer segment membrane|
|glomerular epithelial cell differentiation|
|camera-type eye photoreceptor cell differentiation|
|regulation of epithelial cell differentiation involved in kidney development|
|glomerular epithelium development|
|retina layer formation|
|microvillus membrane|
|epithelial cell differentiation involved in kidney development|
|photoreceptor cell maintenance|
|positive regulation of kidney development|
|cell differentiation involved in kidney development|
|eye photoreceptor cell differentiation|
|retina morphogenesis in camera-type eye|
|cholesterol binding|
|glomerulus development|
|regulation of kidney development|
|photoreceptor cell differentiation|
|neural retina development|
|positive regulation of epithelial cell differentiation|
|photoreceptor outer segment|
|microvillus|
|retina homeostasis|
|endoplasmic reticulum-Golgi intermediate compartment|
|nephron epithelium development|
|camera-type eye morphogenesis|
|nephron development|
|kidney epithelium development|
|retina development in camera-type eye|
|regulation of epithelial cell differentiation|
|vesicle|
|eye morphogenesis|
|tissue homeostasis|
|cilium|
|sensory organ morphogenesis|
|kidney development|
|renal system development|
|cadherin binding|
|camera-type eye development|
|urogenital system development|
|apical plasma membrane|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|eye development|
|visual system development|
|sensory system development|
|sensory organ development|
|cell surface|
|epithelial cell differentiation|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|neuron differentiation|
|endoplasmic reticulum|
|epithelium development|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|extracellular space|
|neurogenesis|
|homeostatic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.72|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.75|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17346
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PROM1 Expression in NALM6 Cells: -1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>